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MetabolomicsOmega-3 polyunsaturated fatty acids modulate gut microbiota-derived 18β-glycyrrhetinic acid to alleviate type 1 diabetes mellitus_fecal_Omega-3 PUFAs

Background

Omega-3 polyunsaturated fatty acids (PUFAs) are known to protect against type 1 diabetes mellitus (T1DM), but how they act through the gut-islet axis is not fully understood. This study explored how Omega-3 PUFA-influenced gut microbiota and their metabolites help protect pancrea...

2026-06-13 | MTBLS13979 | MetaboLights
MetabolomicsOmega-3 polyunsaturated fatty acids modulate gut microbiota-derived 18β-glycyrrhetinic acid to alleviate type 1 diabetes mellitus

Background

Omega-3 polyunsaturated fatty acids (PUFAs) are known to protect against type 1 diabetes mellitus (T1DM), but how they act through the gut-islet axis is not fully understood. This study explored how Omega-3 PUFA-influenced gut microbiota and their metabolites help protect pancrea...

2026-06-13 | MTBLS13006 | MetaboLights
MetabolomicsOmega-3 polyunsaturated fatty acids modulate gut microbiota-derived 18β-glycyrrhetinic acid to alleviate type 1 diabetes mellitus

Background

Omega-3 polyunsaturated fatty acids (PUFAs) are known to protect against type 1 diabetes mellitus (T1DM), but how they act through the gut-islet axis is not fully understood. This study explored how Omega-3 PUFA-influenced gut microbiota and their metabolites help protect pancrea...

2026-06-13 | MTBLS13174 | MetaboLights
MetabolomicsEssential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain

Omega-3 fatty acids (n-3 polyunsaturated fatty acids; n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs. Low maternal intake of n...

2020-11-03 | MTBLS1952 | MetaboLights
MetabolomicsIntermittent fasting mobilizes polyunsaturated fatty acid eicosapentaenoic acid inducing ferroptosis to suppress hepatocellular carcinoma progression
Metabolic dysfunction-associated fatty liver disease (MAFLD) has become a leading cause of hepatocellular carcinoma (HCC), prompting ongoing efforts to understand its mechanisms and develop targeted therapies. Although dietary interventions such as fasting influence tumor growth, the underlying mole...
2026-08-28 | MTBLS15484 | MetaboLights
MetabolomicsHow Does the Seed Pre-germinative Metabolism Fight against Imbibition Damage? Emerging Roles of Fatty Acid Cohort and Antioxidant Defence

During seed imbibition, lipids are engaged in membrane reorganization while facing free radical-mediated oxidative injury. In the present work, we explored changes in lipid components at different timepoints of imbibition (0.5, 2, 4, 6, and 8 h) in the legume Medicago truncatula, by combining bio...

2019-10-14 | MTBLS181 | MetaboLights
TranscriptomicsTranscription profiling of mouse small intestine following a four week diet high high in polyunsaturated fatty acids of marine origin
Dietary polyunsaturated fatty acids (PUFA) act as potent natural hypolipidemics and are linked to many health benefits in humans and in animal models. Mice fed long-term a high fat diet, in which medium-chain alpha linoleic acid (ALA) was partially replaced by long-chain docosahexaenoic (DHA) and ei...
ORGANISM(S): Mus musculus 
2009-04-16 | E-GEOD-11936 | biostudies-arrayexpress
TranscriptomicsGene expression in colorectal liver metastasis tissues from EPA-treated patients
Eicosapentaenoic acid in its free fatty acid form (EPA-FFA), 2g daily, is safe and well-tolerated in patients undergoing liver resection surgery for colorectal liver metastasis.Oral EPA incorporates into colorectal liver metastasis tissue. EPA-FFA treatment is associated with reduced vascularity of ...
ORGANISM(S): Homo sapiens 
2016-03-16 | E-GEOD-79266 | biostudies-arrayexpress
ProteomicsLysine iminylation derived from ω-3 polyunsaturated fatty acids
Protein post-translational modifications (PTMs) play a central role for regulating protein function and cellular processes, with many PTMs arising from reactions with electrophilic metabolites. Here we extend the known landscape of PTMs with the discovery of ‘lysine C3-iminylation’, the conjugation ...
ORGANISM(S): Mus musculus (Mouse) Caenorhabditis elegans 
2026-08-19 | PXD076406 | Pride
Proteomics C. elegans Cytochrome p450 Omega-3 polyunsaturated fatty acid Post-translational modification 
TranscriptomicsThe consequences of n-3 polyunsaturated fatty acids (PUFA) depletion on hepatic lipid metabolism in mice
In the present study, we investigated the consequences of n-3 polyunsaturated fatty acids (PUFA) depletion on hepatic lipid metabolism in mice fed during three months with a diet presenting a high n-6/n-3 PUFA ratio to induce n-3 PUFA depletion. Microarray analyses were performed to identify the mol...
ORGANISM(S): Mus musculus 
2011-08-25 | E-GEOD-26986 | biostudies-arrayexpress
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