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GenomicsMCL cel lines upon OMP-52M51 treatment
MCL cel lines upon OMP-52M51 treatment
PRJNA515904 | ENA
TranscriptomicsTranscription profiling of mouse olfactory epithelium from heterozygous and homozygouse OMP-GFP animals
OMP is expressed only in mature olfactory sensory neurons, arguing that its function is specially suited to the needs of OSNs. However none of the properties of OMP suggest any direct role in regulating gene expression in OSNs. Our data confirms that gene expression in the olfactory epithelium of m...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4927 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-sequencing of OMP-GFP mouse olfactory sensory neurons
We sequenced the transcriptome of 34 single olfactory sensory neurons (OSNs) manually picked from OMP-GFP mice, ensuring the cells expressed high levels of GFP, a marker of mature OSNs. We pooled the olfactory mucosa from 2 male and 2 female animals, to obtain single-cell suspensions for cell pickin...
ORGANISM(S): Mus musculus 
2020-02-04 | E-MTAB-8285 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of the murine olfactory receptor neuron transcriptome
The recent development of next-generation sequencing (NGS) techniques encouraged us to assess the transcriptome of the murine OE. We analyzed RNA from OEs of female and male adult mice and from fluorescence-activated cell sorting (FACS)-sorted olfactory receptor neurons (ORNs) obtained from transgen...
ORGANISM(S): Mus musculus 
2015-01-21 | E-GEOD-53793 | biostudies-arrayexpress
GenomicsRNASeq data from OMP-52M51 acute treated T-ALL PDX mice
RNASeq data from OMP-52M51 acute treated T-ALL PDX mice
PRJNA933227 | ENA
GenomicsAnalysis for transcriptome profiling changes in 4'-O-methylpyridoxine (OMP) treated leukemic cells
Analysis for transcriptome profiling changes in 4'-O-methylpyridoxine (OMP) treated leukemic cells
PRJNA587487 | ENA
TranscriptomicsEffect of OMP on gene expression in the olfactory epithelium
OMP is expressed only in mature olfactory sensory neurons, arguing that its function is specially suited to the needs of OSNs. However none of the properties of OMP suggest any direct role in regulating gene expression in OSNs. Our data confirms that gene expression in the olfactory epithelium of mi...
ORGANISM(S): Mus musculus 
2007-04-30 | GSE4927 | GEO
TranscriptomicsMCL cel lines upon OMP-52M51 treatment
Treatment with the monoclonal Notch1-antibody OMP-52M51 prevented DLL4-dependent activation of Notch1 and suppressed induction of Notch target genes in NOTCH1 mutated cell lines
ORGANISM(S): Homo sapiens 
2019-01-19 | GSE125349 | GEO
TranscriptomicsRNASeq data from OMP-52M51 acute treated T-ALL PDX mice
We recently demonstrated that a human Notch1-specific neutralizing antibody (OMP-52M51) was very effective in T-ALL patient derived xenografts (PDX) bearing NOTCH1/FBW7 mutations. To evaluate the transcriptomic downstream effects of anti-NOTCH1 therapy, we perform RNA-Seq analysis in leukemia cells ...
ORGANISM(S): Homo sapiens 
2023-09-13 | GSE224988 | GEO
TranscriptomicsTranscription profiling of mouse olfactory sensory neurons
The overall aim of the experiment is to understand the phenotype of mature mouse olfactory sensory neurons by analyzing the transcripts expressed and enriched in them as compared to the rest of the cell types in the olfactory epithelium (consisting of immature neurons, supporting cells, progenitor c...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4915 | biostudies-arrayexpress
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