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GenomicsMLL1 is essential for the senescence-associated secretory phenotype [ChIP-Seq]
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the se...
ORGANISM(S): Homo sapiens 
2016-02-23 | E-GEOD-78141 | biostudies-arrayexpress
TranscriptomicsHistone H3.3 and its proteolytically processed form drive a cellular senescence program
In this study, we have uncovered novel proteolytic processing of the histone H3 tail in senescence models in primary fibroblasts and melanocytes. Cleavage of H3 tail occurs at two distinct residues and is mediated by Cathepsin L. We show that variant H3.3 is preferentially cleaved, and that cleaved ...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-55949 | biostudies-arrayexpress
TranscriptomicsMLL1 is essential for the senescence-associated secretory phenotype [RNA-Seq]
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the se...
ORGANISM(S): Homo sapiens 
2016-02-23 | E-GEOD-78138 | biostudies-arrayexpress
GenomicsMLL1 is essential for the senescence-associated secretory phenotype
This SuperSeries is composed of the SubSeries listed below. Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory respon...
ORGANISM(S): Homo sapiens 
2016-02-22 | E-GEOD-78142 | biostudies-arrayexpress
ProteomicsPhosphoproteome dynamics in onset and maintenance of Oncogene-Induced Senescence, proteome dataset
Expression of the BRAFV600E oncoprotein is known to cause benign lesions, for example melanocytic nevi (moles). In spite of the oncogenic function of mutant BRAF, these lesions are arrested by a cell-autonomous mechanism called Oncogene-Induced Senescence (OIS). Infrequently, nevi can progress to ma...
ORGANISM(S): Homo sapiens (Human) 
2015-01-13 | PXD001068 | Pride
Cancer Phosphoproteome Proteome Oncogene-induced senescence 
GenomicsGenome wide mapping of H3K27ac in IMR90 oncogene induced senescence
Genome wide mapping of H3K27ac in IMR90 oncogene induced senescence
PRJNA610856 | ENA
GenomicsDNMT1 drives 4D genome rewiring during oncogene induced senescence
DNMT1 drives 4D genome rewiring during oncogene induced senescence
PRJNA535444 | ENA
GenomicsOncogene inactivation induced senescence facilitates tumor relapse
Oncogene inactivation induced senescence facilitates tumor relapse
PRJEB78692 | ENA
GenomicsGene regulation by TLR2 and TLR10 in oncogene-induced senescence
Gene regulation by TLR2 and TLR10 in oncogene-induced senescence
PRJNA524181 | ENA
GenomicsGlobal transcriptional profiles of primary and secondary cellular senescence in vivo by oncogene-induced senescence (OIS) and stress-induced senescence (SIS) [scRNA-seq]
Global transcriptional profiles of primary and secondary cellular senescence in vivo by oncogene-induced senescence (OIS) and stress-induced senescence (SIS) [scRNA-seq]
PRJNA1014391 | ENA
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