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MetabolomicsLactobacillus acidophilus potentiates oncolytic virotherapy through modulating gut microbiota homeostasis in hepatocellular carcinoma
Oncolytic viruses (OVs) hold promise for cancer treatment. However, the antitumor efficacy is limited. Microbiota plays a pivotal role in cancer treatment and its impact on oncolytic virotherapy is unknown. Here, we show that VSVΔ51 has higher antitumor efficacy for hepatocellular carcinoma in the a...
2025-03-14 | MTBLS12297 | MetaboLights
MetabolomicsEngineered Oncolytic VSV Enhances Tumor Killing in HBV-Positive HCC
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, with chronic hepatitis B virus (HBV) infection being a major contributor to its development. Despite this, effective treatment for HBV-associated HCC remains a significant challenge. In this study, we combined the s...
2025-07-17 | MTBLS12196 | MetaboLights
TranscriptomicsModel based Rational Design of an Oncolytic Virus with Improved Therapeutic Potential
Oncolytic viruses are complex biological agents that interact at multiple levels with both tumor and normal tissues. Anti-viral pathways induced by interferon are known to play a critical role in determining tumor cell sensitivity and normal cell resistance to infection with oncolytic viruses. Here ...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-MTAB-1636 | biostudies-arrayexpress
TranscriptomicsOncolytic Reovirus mediates innate-driven SARS-CoV-2 elimination in the absence of cell toxicity
Interplay between type I interferon (IFN) driven innate responses and viral antagonism strongly influences SARS-CoV-2 transmission and the COVID-19 disease course. Hence, variant adaptation includes diminished induction of IFN stimulated genes (ISG) and/or evasion of their effector functions. Exogen...
ORGANISM(S): Homo sapiens 
2026-04-15 | E-MTAB-16855 | biostudies-arrayexpress
ProteomicsNATCANCER-A16341B 1 2 iNV GOV 3 4GOV
Oncolytic viruses (OVs) are replication-competent viruses that selectively infect tumor cells and induce anti-tumor responses. However, systemic delivery is limited by neutralizing antibodies and poor intratumoral bioavailability. We developed iNV-GOV, a tumor-targeted, low-immunogenic platform that...
ORGANISM(S): Homo sapiens (Human) 
2025-10-03 | PXD067837 | Pride
Inv gov and gov 
TranscriptomicsSubclone of resistant CT26 murine tumor shows high sensitivity to VA7 virotherapy: A novel system to study innate immunity and antigen dominance in oncolytic immuno-virotherapy
Recently, attenuated Semliki Forest virus vector VA7 completely eliminated type I interferon (IFN) unresponsive human U87 glioma xenografts while IFN responsive mouse GL261 and CT-2A gliomas proved refractory to the oncolytic virotherapy. Here we describe in two clones of a well established Balb/c m...
ORGANISM(S): Mus musculus 
2014-09-05 | E-GEOD-53001 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse with human solid tumors eradicated with an intravenously injected light-emitting oncolytic Vaccinia virus
Previously we reported that a recombinant vaccinia virus (VACV) carrying a light-emitting fusion gene enters, replicates in, and reveals the locations of tumors in mice. A new recombinant VACV, GLV-1h68, as a simultaneous diagnostic and therapeutic agent, was constructed by inserting three expressio...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8513 | biostudies-arrayexpress
TranscriptomicsResistance of primary ovarian cancer cells to oncolytic adenoviruses part2 of 2
The mechanisms of primary ovarian cancer cells for resistance to viral oncolysis were investigated using Ad5/35.IR.E1A/TRAIL on clonal cultures derived from ovc316m cells. Part 2 of 2, 26 clonal ovc316m cultures additionally to Resistance of primary ovarian cancer cells to oncolytic adenoviruses par...
ORGANISM(S): Homo sapiens 
2009-04-01 | E-GEOD-15351 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human DU-145, PC-3MM2 cell lines treated with irradiation reveals Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation
Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation
ORGANISM(S): Homo sapiens 
2009-05-13 | E-MEXP-2172 | biostudies-arrayexpress
ModelsGevertz2018 - Cancer Treatment with Oncolytic Viruses and Dendritic Cell injections original model
The model is based on 'Developing a Minimally Structured Mathematical Model of Cancer Treatment with Oncolytic Viruses and Dendritic Cell Injections', PMID:30510594. Author:Jana L.Gevertz and Joanna R.Wares. This model describes the original mathematical model described in section 2.1. Built by COPA...
2024-09-02 | BIOMD0000000816 | BioModels
Immuno-oncology 
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