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TranscriptomicsChromosomal changes in primary human uveal melanomas
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-42740 | biostudies-arrayexpress
TranscriptomicsChromosomal changes in primary human uveal melanomas [UCSF]
Uveal melanoma is the most common cancer of the eye arising from melanocytes within the choroid, ciliary bodies and iris. Almost half of uveal melanomas metastasize hematogenously to distant organs, most often the liver, where the disease becomes fatal. One of the first genetic alterations to be i...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-42739 | biostudies-arrayexpress
TranscriptomicsChromosomal changes in primary human uveal melanomas [RPCI]
Uveal melanoma is the most common cancer of the eye arising from melanocytes within the choroid, ciliary bodies and iris. Almost half of uveal melanomas metastasize hematogenously to distant organs, most often the liver, where the disease becomes fatal. One of the first genetic alterations to be i...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-42738 | biostudies-arrayexpress
TranscriptomicsGene expression changes resulting from the stable loss of BAP1 in uveal melanoma cell lines
Uveal melanoma is a highly aggressive cancer with a strong propensity for metastasis, yet little is known about the biological mechanisms underlying this metastatic potential. We recently showed that most metastasizing uveal melanomas, which exhibit a class 2 gene expression profile, contain inactiv...
ORGANISM(S): Homo sapiens 
2013-09-06 | E-GEOD-48863 | biostudies-arrayexpress
ProteomicsOncogenic pathways in uveal melanoma identified by phosphoproteomic analysis
The uveal melanoma cell lines MP41 and MP46 driven by oncogenic G11 (Q209L) and Gq (Q209L), respectively, and a control cell line OCM-1A driven by oncogenic BRAF (V600E) were treated for 24 hours with FR900359, a highly specific inhibitor of Gq/11. Protein extracts were collected and TMT labeled pri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-11 | MSV000090700 | MassIVE
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