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GenomicsBivalent Chromatin Marks Developmental Regulatory Genes in the Mouse Embryonic Germline in Vivo
We developed a ChIP protocol for the analysis of histone marks using less than 10,000 cells per IP, and used it to investigate the chromatin state of E11.5 mouse primordial germ cells (PGCs). A genome-wide ChIP-Seq analysis of E11.5 PGCs revealed a distribution of H3K4me3/H3K27me3 bivalent domains h...
ORGANISM(S): Mus musculus 
2013-05-30 | E-GEOD-46396 | biostudies-arrayexpress
TranscriptomicsFragSeq: transcriptome-wide RNA structure probing using high-throughput sequencing.
To accelerate previous RNA structure probing approaches, which focus on analyzing one RNA sequence at a time, we have developed FragSeq, a high-throughput RNA structure probing method that uses high-throughput RNA sequencing to identify single-stranded RNA (ssRNA) regions from fragments generated by...
ORGANISM(S): Mus musculus 
2010-11-07 | E-GEOD-24622 | biostudies-arrayexpress
TranscriptomicsThe polyA+ transcriptomes of mouse embryonic stem cells and their derived neural precursors from strand-specific RNA-Seq
We have examined the nuclear (nuc) and cytoplasmic (cyt) polyA+ transcriptomes of undifferentiated mouse embryonic stem cells (un) and cells differentiated to neural precursors (d5) using strand-specific RNA-Seq. The 46C mouse embryonic stem cell line was used for this study. Two cell types were exa...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-38990 | biostudies-arrayexpress
TranscriptomicsComparison of the translational program in oocytes from wild type and Areg KO mice
The study tests the hypothesis that maternal mRNA translation in oocytes is sensitive to the environment in which the oocytes mature. Amphiregulin (AREG) is a critical signal for oocyte maturation but also for oocyte developmental competence. Here we have used a genome-wide approach to determine whe...
ORGANISM(S): Mus musculus 
2013-10-02 | E-GEOD-46640 | biostudies-arrayexpress
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