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TranscriptomicsJMJD2B knockdown treatment in normoxia and hypoxia
Estrogen receptor alpha plays a critical role in breast cancer and is a major target in endocrine therapy. HIF-1 alpha have been associated with ER alpha and predict a worse outcome. Recent studies indicate that histone demethylase JMJD2B is a HIF-1 alpha target. However, little is known about the b...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-18384 | biostudies-arrayexpress
TranscriptomicsRNA-seq
Comprehensive analysis of coding and non -coding transcriptome using ribo-depleted total RNA-seq and poly A selected RNA-seq of MCF-7 cells grown in hypoxia and normoxia. Breast cancer cell line (MCF-7) is cultured in normoxic condition (21% O2) and hypoxic condition (1%O2) for 24 hours. Expression...
ORGANISM(S): Homo sapiens 
2014-02-10 | E-MTAB-1994 | biostudies-arrayexpress
GenomicsChIP-seq
Genome wide analysis RNA polymerase II (RNA Pol II) and histone marker H3K4me3 in hypoxia and normoxia using ChIP-seq. Breast cancer cell line (MCF-7) is cultured in normoxic condition (21% O2) and hypoxic condition (0.5%O2) for 16 hours. Immunoprecipitation of RNA Pol II and H3K4me3.
ORGANISM(S): Homo sapiens 
2014-02-10 | E-MTAB-1995 | biostudies-arrayexpress
TranscriptomicsProfiling transcriptional and translational response to anoxia or hypoxia of genes in DNA damage response and repair pathways in human fibroblast and prostate cancer cells using NanoString nCounter.
Identification of genes in DNA damage response and repair pathways differentially transcribed or translated under anoxia or hypoxia in GM05757 normal human fibroblast cells and DU145 human prostate cancer cells. Comparison of mRNA abundance and translation efficiency of genes in DNA damage response ...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-52461 | biostudies-arrayexpress
TranscriptomicsHypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER [HMLER]
MicroRNAs are small regulatory RNAs that post-transcriptionally control gene expression. Reduced expression of DICER, the enzyme involved in microRNA processing, is frequently observed in cancer and is associated with poor clinical outcome in various malignancies. Yet the underlying mechanisms are n...
ORGANISM(S): Homo sapiens 
2014-09-30 | E-GEOD-61721 | biostudies-arrayexpress
TranscriptomicsHypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER [MCF7]
MicroRNAs are small regulatory RNAs that post-transcriptionally control gene expression. Reduced expression of DICER, the enzyme involved in microRNA processing, is frequently observed in cancer and is associated with poor clinical outcome in various malignancies. Yet the underlying mechanisms are n...
ORGANISM(S): Homo sapiens 
2014-09-30 | E-GEOD-61720 | biostudies-arrayexpress
UnknownGlobal data set of long-term summertime vertical temperature profiles in 153 lakes.
Not available
S-EPMC8339007 | biostudies-literature
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