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TranscriptomicsProfiling premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis
Lung squamous cell carcinoma (SCC) is thought to arise from premalignant lesions in the airway epithelium, therefore studying these lesions is critical for understanding lung carcinogenesis. We performed RNA sequencing on laser-microdissected representative cell populations along the SCC pathologica...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-49155 | biostudies-arrayexpress
TranscriptomicsExpression and MeDIP microarray data from IL13-induced allergic airway inflammation of mice lungs
This SuperSeries is composed of the following subset Series: GSE35979: Gene expression data from IL13-induced allergic airway inflammation of mice lungs GSE35980: MicroRNA expression data from IL13-induced allergic airway inflammation of mice lungs GSE37079: Methylated DNA immunoprecipitation (MeDIP...
ORGANISM(S): Mus musculus 
2012-04-06 | E-GEOD-37085 | biostudies-arrayexpress
TranscriptomicsGene expression data from IL13-induced allergic airway inflammation of mice lungs
Asthma is a common chronic inflammatory airway condition with a strong genetic and inheritability component, as siblings and first-degree relatives of those with the disease are often affected. For our studies, we used a well-characterized transgenic mouse model of allergic airway inflammation induc...
ORGANISM(S): Mus musculus 
2012-02-23 | E-GEOD-35979 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression data from IL13-induced allergic airway inflammation of mice lungs
Epigenetic changes have been implicated in pathogenesis of asthma. We sought to determine if IL13, a key cytokine in airway inflammation and remodeling, induced miRNAs expression changes in the airways in conjunction with its transcriptional gene regulation. For our studies, we used a well-character...
ORGANISM(S): Mus musculus 
2012-02-23 | E-GEOD-35980 | biostudies-arrayexpress
TranscriptomicsMethylated DNA immunoprecipitation (MeDIP) microarray data from IL13-induced allergic airway inflammation of mouse lungs
Epigenetic changes have been implicated in pathogenesis of asthma. We sought to determine if IL13, a key cytokine in airway inflammation and remodeling, induced epigenetic DNA methylation changes in the airways in conjunction with its transcriptional gene regulation. For our studies, we used a well-...
ORGANISM(S): Mus musculus 
2012-04-06 | E-GEOD-37079 | biostudies-arrayexpress
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