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UnknownThe Y deletion gr/gr and susceptibility to testicular germ cell tumor.
Testicular germ cell tumor (TGCT) is the most common cancer in young men. Despite a considerable familial component to TGCT risk, no genetic change that confers increased risk has been substantiated to date. The human Y chromosome carries a number of genes specifically involved in male germ cell dev...
S-EPMC1285161 | biostudies-literature
UnknownScalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines.
The Cancer Genome Atlas (TCGA) cancer genomics dataset includes over 10,000 tumor-normal exome pairs across 33 different cancer types, in total >400 TB of raw data files requiring analysis. Here we describe the Multi-Center Mutation Calling in Multiple Cancers project, our effort to generate a compr...
S-EPMC6075717 | biostudies-literature
UnknownImpact of the COVID-19 pandemic on surgical care in the Netherlands.

Background

The COVID-19 pandemic caused disruption of regular healthcare leading to reduced hospital attendances, repurposing of surgical facilities, and cancellation of cancer screening programmes. This study aimed to determine the impact of COVID-19 on surgical care in the Netherlands.

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S-EPMC10364688 | biostudies-literature
UnknownlncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.
We characterized the epigenetic landscape of genes encoding long noncoding RNAs (lncRNAs) across 6,475 tumors and 455 cancer cell lines. In stark contrast to the CpG island hypermethylation phenotype in cancer, we observed a recurrent hypomethylation of 1,006 lncRNA genes in cancer, including EPIC1 ...
S-EPMC6143179 | biostudies-literature
UnknownComparative Molecular Analysis of Gastrointestinal Adenocarcinomas.
We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to examine shared and distinguishing molecular characteristics of gastrointestinal tract adenocarcinomas (GIACs). Hypermutated tumors were distinct regardless of cancer type and comprised those enriched for insertions/delet...
S-EPMC5966039 | biostudies-literature
UnknownPan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas.
Although the MYC oncogene has been implicated in cancer, a systematic assessment of alterations of MYC, related transcription factors, and co-regulatory proteins, forming the proximal MYC network (PMN), across human cancers is lacking. Using computational approaches, we define genomic and proteomic ...
S-EPMC5892207 | biostudies-literature
UnknownGenomic and Functional Approaches to Understanding Cancer Aneuploidy.
Aneuploidy, whole chromosome or chromosome arm imbalance, is a near-universal characteristic of human cancers. In 10,522 cancer genomes from The Cancer Genome Atlas, aneuploidy was correlated with TP53 mutation, somatic mutation rate, and expression of proliferation genes. Aneuploidy was anti-correl...
S-EPMC6028190 | biostudies-literature
UnknownIntegrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types.
Protein ubiquitination is a dynamic and reversible process of adding single ubiquitin molecules or various ubiquitin chains to target proteins. Here, using multidimensional omic data of 9,125 tumor samples across 33 cancer types from The Cancer Genome Atlas, we perform comprehensive molecular charac...
S-EPMC5916807 | biostudies-literature
UnknownMolecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers.
Metabolic reprogramming provides critical information for clinical oncology. Using molecular data of 9,125 patient samples from The Cancer Genome Atlas, we identified tumor subtypes in 33 cancer types based on mRNA expression patterns of seven major metabolic processes and assessed their clinical re...
S-EPMC5916795 | biostudies-literature
UnknownPerspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.
The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we present our current understanding of the molec...
S-EPMC5916814 | biostudies-literature
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