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TranscriptomicsQuantitative omics reveals that type I and II IFNs alter bacterial vacuole compositions to restrict infection in macrophages and lungs
The innate defense mechanisms that control infections with intracellular bacteria are still incompletely understood. Here we show that type I and II IFNs are key regulators of the early gene expression and the host-protective immune response during Legionella pneumophila-induced pneumonia. Using mix...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-60085 | biostudies-arrayexpress
TranscriptomicsInnate Immune Recognition of Bacterial Viability Instructs Human T follicular Helper Cell Differentiation
Live attenuated vaccines are often superior to dead vaccines, yet the immunological mechanisms remain largely obscure. We have recently uncovered an inherent capacity of antigen-presenting cells (APC) to discriminate live from killed bacteria by virtue of vita-PAMPs. Here we found that innate recogn...
ORGANISM(S): Homo sapiens 
2016-04-06 | E-GEOD-68255 | biostudies-arrayexpress
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