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MetabolomicsA synthetic antibiotic class with a deeply-optimized design for overcoming bacterial resistance

The lack of new drugs that are effective against antibiotic-resistant bacteria has caused increasing concern in global public health. Based on this study, we report development of a modified antimicrobial drug through structure-based drug design (SBDD) and modular synthesis. The optimal modified ...

2024-07-03 | MTBLS10516 | MetaboLights
TranscriptomicsAutomated array-CGH optimized for archival formalin-fixed, paraffin-embedded tumor material
BACKGROUND: Array Comparative Genomic Hybridization (aCGH) is a rapidly evolving technology that still lacks complete standardization. Yet, it is of great importance to obtain robust and reproducible data to enable meaningful multiple hybridization comparisons. Special difficulties arise when aCGH i...
ORGANISM(S): Homo sapiens 
2010-06-12 | E-GEOD-7122 | biostudies-arrayexpress
TranscriptomicsDigital RNA Sequencing Minimizes Sequence-Dependent Bias and Amplification Noise with Optimized Single Molecule Barcodes
RNA-Seq is a powerful tool for transcriptome profiling, but is hampered by sequence-dependent bias and inaccuracy at low copy numbers intrinsic to exponential PCR amplification. We developed a simple strategy for mitigating these complications, allowing truly digital RNA-Seq. Following reverse tra...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2012-01-07 | E-GEOD-34449 | biostudies-arrayexpress
GenomicsOptimized ATAC-seq library preparation from Drosophila neurons
Optimized ATAC-seq library preparation from Drosophila neurons
PRJNA812007 | ENA
GenomicsEpigenomic profiling by optimized ChIL-seq for tissue
Epigenomic profiling by optimized ChIL-seq for tissue
PRJNA667432 | ENA
ProteomicsBottom-up proteomics with collision energies optimized for identification confidence
Collision energy dependent measurements on HeLa samples and performance assessment at optimized energies on QTof and Orbitrap instruments
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-28 | MSV000086379 | MassIVE
TranscriptomicsSingle cell RNA-sequencing of the human synovium in inflammatory arthritis
The study presents: - an optimized synovium dissociation protocol for single cell RNA-sequencing studies of the human synovium. The protocol enables the isolation of high yield of viable synovial cells from prospectively collected fresh synovial biopsies from patients with inflammatory arthritis wi...
ORGANISM(S): Homo sapiens 
2024-04-21 | E-MTAB-11791 | biostudies-arrayexpress
GenomicsPROstate cancer Medically Optimized genome enhanced ThErapy (PROMOTE)
PROstate cancer Medically Optimized genome enhanced ThErapy (PROMOTE)
PRJNA325180 | ENA
GenomicsAn optimized protocol for single cell transcriptional profiling by combinatorial indexing
An optimized protocol for single cell transcriptional profiling by combinatorial indexing
PRJNA776254 | ENA
GenomicsOptimized low-volume Plasmodium blood sample processing protocols for untargeted transcriptomics
Optimized low-volume Plasmodium blood sample processing protocols for untargeted transcriptomics
PRJNA1251070 | ENA
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