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TranscriptomicssiRNA profiling of human cells knocked down for optineurin
This study aimed to identify genes that are linked with optineurin expression using a combined siRNA-microarray approach Experiment Overall Design: Samples a01, a02 and a03 were treated with siRNA specific for optineurin mRNA Experiment Overall Design: Samples b01, b02 and b03 were treated with wate...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6819 | biostudies-arrayexpress
GenomicsOptineurin depletion in dendritic cells
Optineurin depletion in dendritic cells
PRJNA578699 | ENA
GenomicsOptineurin Shapes Basal and LPS-Induced Transcriptomes in BV2 Microglia
Optineurin Shapes Basal and LPS-Induced Transcriptomes in BV2 Microglia
PRJNA1314160 | ENA
TranscriptomicsOptineurin Shapes Basal and LPS-Induced Transcriptomes in BV2 Microglia
The OPTN gene is linked to neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which are characterized by chronic microglial activation. Optineurin regulates inflammatory signaling, autophagy, and trafficking, but its role in microglia is not well u...
ORGANISM(S): Mus musculus 
2025-11-10 | GSE307044 | GEO
GenomicsOptineurin-deficiency Collapses the Host Endolysosomal Network and Impairs Xenophagy to Accelerate Mycobacterium tuberculosis Growth
Optineurin-deficiency Collapses the Host Endolysosomal Network and Impairs Xenophagy to Accelerate Mycobacterium tuberculosis Growth
PRJNA1515910 | ENA
UnknownCellular and molecular biology of optineurin.
Not available
S-EPMC3673586 | biostudies-literature
TranscriptomicsIdentification of genes that are linked with optineurin expression
This study aimed to identify genes that are linked with optineurin expression using a combined siRNA-microarray approach Keywords: siRNA treatment study
ORGANISM(S): Homo sapiens 
2007-02-02 | GSE6819 | GEO
GenomicsOptineurin inhibition impedes type II collagen challenged dendritic cell migration
Optineurin inhibition impedes type II collagen challenged dendritic cell migration
PRJNA1004646 | ENA
TranscriptomicsOptineurin depletion in dendritic cells
Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) linking innate and adaptive immune response. DCs are crucial for initiating adaptive immune responses for elimination of invading pathogens and also in inducing immune tolerance toward harmless components to maintain immune homeos...
ORGANISM(S): Mus musculus 
2021-10-20 | GSE139175 | GEO
TranscriptomicsOptineurin-deficiency Collapses the Host Endolysosomal Network and Impairs Xenophagy to Accelerate Mycobacterium tuberculosis Growth
Selective autophagy is a host defense mechanism against Mycobacterium tuberculosis (Mtb) that restricts bacterial growth by targeting ubiquitin-coated bacilli for lysosomal degradation via autophagy receptors. Optineurin is a selective autophagy receptor that targets pathogens and modulates immune s...
ORGANISM(S): Mus musculus 
2026-08-25 | GSE344459 | GEO
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