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MetabolomicsAlterations in the oral microbiome and metabolome of methamphetamine addicts

BACKGROUND: Drug addiction can seriously damage human physical and mental health, while detoxification is a long and difficult process. Although studies have reported changes in the oral microbiome of methamphetamine (METH) addicts, the role of the microbiome plays in this proces...

2023-07-24 | MTBLS7807 | MetaboLights
MetabolomicsImpact of oral Chlamydia Vaccination on Host Gut Microbiome and Metabolite Composition

Chlamydia trachomatis, an intracellular pathogen, is recognized as the most common sexually transmitted bacterial infection among women worldwide. Chlamydia infections can lead to undesirable clinical outcomes, including pelvic inflammatory disease and infertility. Recently, the gut has been...

2025-11-07 | MTBLS12603 | MetaboLights
MetabolomicsOral-gut microbiome and plasma metabolome reveal incremental restratification of coronary artery disease from the clinical gray zone
Clinical prediction models have been widely applied for risk stratification of coronary artery disease (CAD), yet approximately 20% to 40% of screened individuals fall into the intermediate-risk interval and face a decision gap. Here, we adopted a two-stage validation design. In the first stage, a c...
2026-08-31 | MTBLS15425 | MetaboLights
MetabolomicsOral dysbiosis initiates periodontal disease in experimental kidney disease

BACKGROUND AND HYPOTHESIS: It is presently unclear why there is a high prevalence of periodontal disease in individuals living with chronic kidney disease. Whilst some have argued that periodontal disease causes chronic kidney disease, we hypothesized that alterations in saliva ...

2025-09-04 | MTBLS1833 | MetaboLights
MetabolomicsSaliva metabolome and microbiome in permanent teeth caries

Metabolites are important determinants of disease progression. In this study, we conducted a case-control study to explore permanent teeth caries-related differences in salivary metabolite profiles and related changes in the composition of the oral microbiota in 200 subjects including 100 caries-...

2024-05-14 | MTBLS4569 | MetaboLights
MetabolomicsOral administration of low-molecular-weight heparin ameliorates colitis by enhancing the gut mucus barrier via microbial tryptophan metabolites

Background and Purpose: Previous studies have reported that oral low molecular weight heparin (LMWH) ameliorated colitis by undefined mechanisms in ulcerative colitis (UC) patients. Our study explored the mechanisms of LMWH on colitis from the perspective of gut microbiota and its metabolites.

2025-10-12 | MTBLS5770 | MetaboLights
MetabolomicsBiological Responses to Tobacco Smoke Exposure in III Children: Inflammatory Processes and the Oral Microbiome
Not available
ORGANISM(S): Homo sapiens 
ST001200 | MetabolomicsWorkbench
ProteomicsUltra-deep and quantitative saliva proteome reveals dynamics of the oral microbiome
The oral cavity is home to one of the most diverse microbial community of the human body and a major entry portal for pathogens. Its homeostasis is maintained by saliva, which fulfills key functions including lubrication of food, predigesting and bacterial defense. Consequently, disruptions in saliv...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080862 | MassIVE
MetabolomicsMapping human microbiome drug metabolism by gut bacteria and their genes

Individuals vary widely in their drug responses, which can be dangerous and expensive due to treatment delays and adverse effects. Growing evidence implicates the gut microbiome in this variability, however the molecular mechanisms remain largely unknown. We measured the ability of 76 diverse hum...

2019-07-10 | MTBLS896 | MetaboLights
MetabolomicsContributions of the Microbiome-Derived Metabolome for Risk Assessment and Prognostication of Pancreatic Cancer

BACKGROUND Increasing evidence implicates microbiome involvement in the development and progression of pancreatic ductal adenocarcinoma (PDAC). Studies suggest that reflux of gut or oral microbiota can lead to colonization in the pancreas, resulting in dysbiosis that culminates ...

2023-08-09 | MTBLS7260 | MetaboLights
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