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TranscriptomicssVEGFR-1 signaling through α5β1 integrin
Soluble VEGFR-1 (sVEGFR-1) acts both as a decoy receptor for VEGFs and as an extracellular matrix protein for α5β1 integrin. A sVEGFR-1-derived peptide that interacts with α5β1 integrin promotes angiogenesis. However, canonical signal downstream integrin activation is not induced, resulting into...
ORGANISM(S): Homo sapiens 
2014-01-20 | E-GEOD-32560 | biostudies-arrayexpress
TranscriptomicsMonozygotic twins discordant for recessive dystrophic epidermolysis bullosa phenotype highlight the role of TGF-β signalling in modifying disease severity
Recessive dystrophic epidermolysis bullosa (RDEB) is a genodermatosis characterized by fragile skin forming blisters that heal invariably with scars. It is due to mutations in the COL7A1 gene encoding type VII collagen, the major component of anchoring fibrils connecting the cutaneous basement membr...
ORGANISM(S): Homo sapiens 
2014-04-03 | E-GEOD-51056 | biostudies-arrayexpress
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