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TranscriptomicsHITS-CLIP analysis uncovers a link between the Kaposi's sarcoma associated herpesvirus ORF57 protein and host pre-mRNA metabolism
The Kaposi's sarcoma associated herpesvirus (KSHV) is an oncogenic virus that causes Kaposi's sarcoma, primary effusion lymphoma (PEL), and some forms of multicentric Castleman's disease. The KSHV ORF57 protein is a conserved posttranscriptional regulator of gene expression that is essential for vir...
ORGANISM(S): Homo sapiens 
2015-02-01 | E-GEOD-64413 | biostudies-arrayexpress
ProteomicsRepurposing Herpesvirus Protein ORF57 to Inhibit TDP-43 Aggregation
The integrated stress response (ISR) is a major element of translation control. The ISR is beneficial in responding to acute stresses, but in human disease a chronic, persistent stress response can contribute to the disease process. Many studies manipulate the ISR by targeting just one protein. Howe...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD039246 | Pride
Translational stress response Alzheimer’s disease Als Protein aggregation Tdp-43 
GenomicsCLIP-seq analysis of KSHV ORF57-associated RNAs
CLIP-seq analysis of KSHV ORF57-associated RNAs
PRJNA744779 | ENA
GenomicsViral RNA-binding protein KSHV ORF57 and host transcriptome
Viral RNA-binding protein KSHV ORF57 and host transcriptome
PRJNA744781 | ENA
GenomicsGenome-wide analysis of KSHV splicing regulation by ORF57
Genome-wide analysis of KSHV splicing regulation by ORF57
PRJNA799914 | ENA
OtherCLIP-seq analysis of KSHV ORF57-associated RNAs
Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 is a viral RNA-binding protein essential for viral lytic gene expression. ORF57 binds to target RNA directly via interaction with cellular cofactors. To investigate the entire repertoire of ORF57-associated RNAs we performed UV cross-linking immun...
ORGANISM(S): Homo sapiens 
2021-11-08 | GSE179726 | GEO
GenomicsThe effect of ORF57 knockout (KO) on host expression in iSLK/Bac16 cells.
The effect of ORF57 knockout (KO) on host expression in iSLK/Bac16 cells.
PRJNA1081776 | ENA
TranscriptomicsGenome-wide analysis of KSHV splicing regulation by ORF57
Kaposi's sarcoma-associated virus (KSHV) ORF57 is a viral RNA-binding protein required for proper posttranscriptional processing of viral transcripts including RNA splicing. To identify the viral splicing events regulated by ORF57 we performed a genome-wide analysis of RNA splicing of viral RNAs in ...
ORGANISM(S): Homo sapiens 
2022-06-16 | GSE194239 | GEO
UnknownKaposi's sarcoma-associated herpesvirus ORF57 in viral RNA processing.
Not available
S-EPMC2654597 | biostudies-literature
TranscriptomicsViral RNA-binding protein KSHV ORF57 and host transcriptome
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a viral RNA-binding protein ORF57 that plays an essential role in posttranscriptional regulation of viral gene expression. Ectopice expression of KSHV ORF57 in HEK293T cells was evaluated on its effect on host gene expression in the study, with ...
ORGANISM(S): Homo sapiens 
2023-02-13 | GSE179728 | GEO
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