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MetabolomicsSuccinate accumulation drives ischaemia-reperfusion injury during organ transplantation
During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient. Despite its widespread use, our understanding of the m...
2019-09-20 | MTBLS1085 | MetaboLights
MetabolomicsHost autophagy mediates organ wasting and nutrient mobilization for tumor growth
During tumor growth-when nutrient and anabolic demands are high-autophagy supports tumor metabolism and growth through lysosomal organelle turnover and nutrient recycling. Ras-driven tumors additionally invoke non-autonomous autophagy in the microenvironment to support tumor growth, in part through ...
2021-09-24 | MTBLS2771 | MetaboLights
MetabolomicsAn Atlas of Inter-Organ Metabolite Trafficking in Health and Atherogenic Conditions

Mammalian organs continuously exchange circulating metabolites for organismal health and survival. However, the landscape of this fundamental process and its perturbation by diet and disease is unknown. Using arteriovenous metabolomics, tissue transcriptomics, hormone arrays and multiple metaboli...

2025-05-12 | MTBLS10288 | MetaboLights
MetabolomicsOrgan-specific accumulation of flavonoids and terpenoids in Myricaria laxiflora based on non-targeted metabolomics
Background Myricaria laxiflora, an endangered species endemic to the water-level fluctuation zone of the Yangtze River, plays a critical role in riparian ecosystem conservation. However, a comprehensive understanding of its organ-specific metabolic composition remains scarce. Method A non-targeted m...
2026-04-24 | MTBLS14367 | MetaboLights
MetabolomicsOrgan-Resolved Untargeted LC-MS/MS Profiling of Putative Metabolite Families in Aerial Organs of Vitex negundo L

Background/Objectives: Vitex negundo L. is a multi-part medicinal and aromatic plant, but organ-resolved chemical information for its aerial organs remains incomplete. This study generated an exploratory paired untargeted liquid chromatography–tandem mass spectrometry (LC-MS/MS) dataset for flowe...

2026-09-13 | MTBLS15653 | MetaboLights
MetabolomicsA metabolomic study of adipose tissue in mice with a disruption of the circadian system

Adipose tissue functions in terms of energy homeostasis as a rheostat for blood triglyceride, regulating its concentration, in response to external stimuli. In addition it acts as a barometer to inform the central nervous system of energy levels which can vary dramatically between meals and accor...

2017-10-27 | MTBLS380 | MetaboLights
MetabolomicsA metabolomic study of adipose tissue in mice with a disruption of the circadian system

Adipose tissue functions in terms of energy homeostasis as a rheostat for blood triglyceride, regulating its concentration, in response to external stimuli. In addition it acts as a barometer to inform the central nervous system of energy levels which can vary dramatically between meals and accor...

2017-10-27 | MTBLS390 | MetaboLights
MetabolomicsMulti-Organ Metabolomic and Ionomic Characterization of Chronic Alcohol Exposure-Induced Alcoholic Liver Disease
Background: Alcoholic liver disease (ALD) is a prevalent chronic liver disorder worldwide. Chronic alcohol exposure not only damages the liver but also disrupts metabolic and elemental homeostasis in multiple organs. However, its systemic effects remain incompletely understood. This study used an in...
2026-10-08 | MTBLS15954 | MetaboLights
Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
MetabolomicsA metabolomic study of adipose tissue in mice with a disruption of the circadian system

Adipose tissue functions in terms of energy homeostasis as a rheostat for blood triglyceride, regulating its concentration, in response to external stimuli. In addition it acts as a barometer to inform the central nervous system of energy levels which can vary dramatically between meals and accor...

2017-10-27 | MTBLS382 | MetaboLights
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