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ProteomicsQuantitative chromatin protein dynamics during replication origin firing in human cells (part 1)
Accurate genome duplication requires a tightly regulated DNA replication program, which relies on the fine regulation of origin firing. While the molecular steps involved in origin firing have been determined predominantly in budding yeast, the complexity of this process in human cells has yet to be...
ORGANISM(S): Homo sapiens (Human) 
2025-01-24 | PXD047108 | Pride
Dna replication Origin firing Chk1 Kinase Dna damage Chromatin 
ProteomicsQuantitative chromatin protein dynamics during replication origin firing in human cells (part 2)
Accurate genome duplication requires a tightly regulated DNA replication program, which relies on the fine regulation of origin firing. While the molecular steps involved in origin firing have been determined predominantly in budding yeast, the complexity of this process in human cells has yet to be...
ORGANISM(S): Homo sapiens (Human) 
2025-01-24 | PXD058340 | Pride
Dna replication Origin firing Chk1 Kinase Dna damage Chromatin 
GenomicsHigh origin firing capacity leads to ATR inhibitor sensitivity via increased replication catastrophe
High origin firing capacity leads to ATR inhibitor sensitivity via increased replication catastrophe
PRJEB85428 | ENA
GenomicsLSD1 Facilitates Euchromatic Origin Firing and Regulates Replication Timing [RNA-seq]
LSD1 Facilitates Euchromatic Origin Firing and Regulates Replication Timing [RNA-seq]
PRJNA661443 | ENA
GenomicsLSD1 Facilitates Euchromatic Origin Firing and Regulates Replication Timing [Repli-seq]
LSD1 Facilitates Euchromatic Origin Firing and Regulates Replication Timing [Repli-seq]
PRJNA661444 | ENA
GenomicsLSD1 Facilitates Euchromatic Origin Firing and Regulates Replication Timing [ChIP-seq]
LSD1 Facilitates Euchromatic Origin Firing and Regulates Replication Timing [ChIP-seq]
PRJNA661442 | ENA
TranscriptomicsTranscription profiling of yeast strains in which Hsk1-Dfp1 has been tethered near a replication origin
Transcription profiling of strains in which Hsk1-Dfp1 has been tethered near a replication origin.
ORGANISM(S): Schizosaccharomyces pombe 
2008-09-25 | E-MEXP-1811 | biostudies-arrayexpress
GenomicsKMT2C/KMT2D-dependent H3K4me1 mediates DNA replication timing and origin firing
KMT2C/KMT2D-dependent H3K4me1 mediates DNA replication timing and origin firing
PRJNA1164200 | ENA
GenomicsPalbociclib interferes with origin firing in a pRb independent manner
Palbociclib interferes with origin firing in a pRb independent manner
PRJNA748597 | ENA
GenomicsGenome-wide mapping of human DNA-replication origins: levels of transcription at Orc1 sites regulate origin selection and replication timing
We report the genome-wide mapping of Orc1 binding-sites in mammals and their validation as active DNA-replication origins (ORIs). Orc1 sites are universally associated with transcription start sites (TSSs) of coding or non-coding RNAs. Transcription levels at the Orc1 sites directly correlate with r...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-37583 | biostudies-arrayexpress
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