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ProteomicsRegulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2
The regulation of membrane lipid composition is critical for cellular homeostasis. Cells are particularly sensitive to phospholipid saturation, with increased saturation causing membrane rigidification and lipotoxicity. How mammalian cells sense membrane lipid composition and reverse fatty acid (FA)...
ORGANISM(S): Homo sapiens (Human) 
2022-08-10 | PXD034835 | Pride
Ap-ms Tmt Oritrap fusion 
ProteomicsProteomic characterization of Withaferin A-targeted protein networks for the treatment of monoclonal myeloma gammopathies
Withaferin A (WA), a natural steroid lactone from the plant Withania Somnifera, has been used for many years in traditional Ayurveda medicine to treat inflammation-related conditions, such as ulcers and rheumatism. Today, WA is most often studied because of its antitumor properties. Although many in...
ORGANISM(S): Homo sapiens (Human) 
2018-02-23 | PXD006528 | Pride
Withaferin a Quantitative chemoproteomics Quantitative differential expression analysis Multiple myeloma 
ProteomicsSite-specific N-glycoproteomic analysis of Intrahepatic cholangiocarcinoma and Hepatocellular carcinoma
In this study,we performed integrated glycoproteomic and global proteomic analysis of tumor tissues of ICC and HCC to investigate the differences in site-specific glycosylation and proteins between ICC and HCC tumors. The paired paracancer tissue were also included as controls to determine the site-...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD020277 | Pride
Intrahepatic cholangiocarcinoma(icc) Intact glycopeptide Site-specific glycosylation Hepatocellular carcinoma(hcc) Glycoproteome Lc-ms/ms 
ProteomicsAn endo-acting galactanase with a type II signal peptide confers keystone status to arabinogalactan degrading bacteria of the human gut microbiota
Glycans, the major source of energy for the human gut microbiota (HGM), are metabolised by numerous members of the Bacteroides genus. Arabinogalactan proteins (AGPs) are a ubiquitous and highly heterogenous group of plant glycans in which a B1,3-galactan backbone and B1,6-galactan side chains are co...
ORGANISM(S): Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) Bacteroides cellulosilyticus 
2018-07-03 | PXD010274 | Pride
Glycan degradation Keystone organism Gut microbiota 
ProteomicsTitle: Site specific O-GlcNAcylation of progesterone receptor (PR) supports PR attenuation of interferon stimulated genes (ISGs) and tumor growth in breast cancer
Hormone receptor (HR) positive breast cancer, defined by expression of estrogen (ER) and/or progesterone (PR) receptor expression, is the most commonly diagnosed type of breast cancer. PR alters the transcriptional landscape to support tumor growth in concert with or independent of ER. Understanding...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-06-17 | MSV000095057 | MassIVE
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