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Transcriptomicsp27Kip1 regulates cell cycle progression by modulating the expression of p21Cip1
In addition to its classical role as a CDK inhibitor, p27 also acts as a transcriptional regulator. We found that at early passages, embryonic fibroblasts from p27-/- mouse show reduced expression of genes involved in DNA replication and progress slowly through the cell cycle. These cells have high ...
ORGANISM(S): Mus musculus 
2016-06-09 | E-MTAB-2790 | biostudies-arrayexpress
TranscriptomicsRapid conversion of fibroblasts into functional forebrain GABAergic interneurons by direct genetic reprogramming
Transplantation of GABAergic interneurons (INs) can sustain long-standing benefits in animal models of epilepsy and other neurological disorders. In a therapeutic perspective, a renewable source of functional GABAergic INs is needed. Here, we identified five factors (Foxg1, Sox2, Ascl1, Dlx5 and Lhx...
ORGANISM(S): Mus musculus 
2015-12-15 | E-GEOD-74065 | biostudies-arrayexpress
UnknownVulnerability of marine megafauna to global at-sea anthropogenic threats.
Not available
S-EPMC12856791 | biostudies-literature
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