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GenomicsGenome-wide maps of Tbx3 binding sites in mouse ESCs
Induced pluripotent stem (iPS) cells can be obtained through the introduction of defined factors into somatic cells. The combination of Oct4, Sox2 and Klf4 (OSK) constitutes the minimal requirement for generating iPS cells from mouse embryonic fibroblasts (MEFs). Through the genomic analyses of ESC ...
ORGANISM(S): Mus musculus 
2009-12-04 | E-GEOD-19219 | biostudies-arrayexpress
GenomicsGenome-wide mapping of PRDM14 binding sites in human embryonic stem cells
PRDM14 belongs to the PR (PRDI-BF1 and RIZ) domain proteins (PRDM) family which is a subclass of the SET domain proteins, a common domain found in histone modifying enzymes. PRDM14 has been previously implicated to regulate self-renewal of hESCs as knock-down of PRDM14 induced expression of differen...
ORGANISM(S): Homo sapiens 
2010-10-20 | E-GEOD-22767 | biostudies-arrayexpress
GenomicsGraded Nodal/Activin Signaling Governs ES Cell Fate Decisions via Differential Recruitment of Phospho-Smad2 to Oct4 and Distinct Target Gene Subsets.
The Nodal/Activin morphogens are secreted signaling molecules that form concentration gradients during early embryogenesis providing stem cells with positional information and differentiation instructions important for embryonic patterning. The molecular basis driving stem cell interpretation of sig...
ORGANISM(S): Mus musculus 
2011-01-31 | E-GEOD-23581 | biostudies-arrayexpress
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