Acute tissue injuries trigger rapid cellular damage, but cell-intrinsic protective programs attenuate pathology through regulatory axes. Here, we demonstrate that Orosomucoid 2 (ORM2), a hepatokine, is significantly upregulated during drug-induced acute liver injury. Knock out Orm2 exacerbates liver...
Upon liver injury, altered cholangiocyte functions can lead to a process referred to as ductular reaction (DR), which is an umbrella term harboring not excessive cell proliferation, but also intricate inflammation and fibrogenesis modulation. DR has been considered as an essential hallmark and promi...
Non-alcoholic fatty liver disease (NAFLD) is caused by imbalance in lipid metabolism. In this study, we show that the hepatokine Orosomucoid 2 (ORM2) is a key regulator of de novo lipogenesis in the liver. Hepatic and plasma ORM2 levels are markedly decreased in obese murine models and NAFLD patient...
