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TranscriptomicsGenetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma
Asthma is caused by a combination of poorly understood genetic and environmental factors. We found multiple markers on chromosome 17q21 to be strongly and reproducibly associated with childhood onset asthma in family and case-referent panels with a combined P < 10-12. In independent replication stu...
ORGANISM(S): Homo sapiens 
2007-11-09 | E-GEOD-8052 | biostudies-arrayexpress
ProteomicsORMDL3-mediated bronchial epithelial pyroptosis leads to lung inflammatory in obese asthmatic mice
Obese asthma is a chronic disease that poses a serious threat to children's health, resulting in more severe wheezing, earlier airway remodelling, and insensitivity to hormone therapy. Despite its clinical importance, knowledge on the underlying mechanisms of this disease remains limited. This study...
ORGANISM(S): Mus Musculus 
2023-07-07 | PXD043630 |
TranscriptomicsExpression data from ORMDL3 knockdown in the A549 Human Lung Epithelial cell line
Asthma is characterized by intermittent inflammation of the airways, airflow limitation and wheeze. The ORMDL3 locus on chromosome 17q21 confers the major genetic susceptibility to childhood asthma. Although sphingolipids are important in immune signalling, the mechanisms of action of ORMDL3 on airw...
ORGANISM(S): Homo sapiens 
2018-11-21 | GSE92484 | GEO
GenomicsRegulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock
Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock
PRJNA561705 | ENA
UnknownRegulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock.
Not available
S-EPMC6764692 | biostudies-literature
TranscriptomicsGenetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma
Asthma is caused by a combination of poorly understood genetic and environmental factors. We found multiple markers on chromosome 17q21 to be strongly and reproducibly associated with childhood onset asthma in family and case-referent panels with a combined P < 10-12. In independent replication stud...
ORGANISM(S): Homo sapiens 
2007-07-01 | GSE8052 | GEO
UnknownNeutrophilia in severe asthma is reduced in Ormdl3 overexpressing mice.
Not available
S-EPMC9990076 | biostudies-literature
UnknownSimultaneous deletion of ORMDL1 and ORMDL3 proteins disrupts immune cell homeostasis.
Not available
S-EPMC11074395 | biostudies-literature
UnknownORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48.
Not available
S-EPMC3940275 | biostudies-literature
UnknownAsthma Susceptibility Gene ORMDL3 Promotes Autophagy in Human Bronchial Epithelium.
Not available
S-EPMC9163638 | biostudies-literature
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