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UnknownAltered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci.
Not available
S-EPMC5388550 | biostudies-literature
MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
TranscriptomicsMacrophage samples from the HMDP
Identify genes involved in regulation of inflammatory responses and gene-environemnt interactions, in macrophages from a set of mouse inbred strains termed the HMDP. The HMDP is a genetically diverse mapping panel comprised of classical inbred and recombinant inbred wild type mice. The RMA values o...
ORGANISM(S): Mus musculus 
2012-10-26 | E-GEOD-38705 | biostudies-arrayexpress
GenomicsNatural genetic variation perturbs collaborative transcription factor binding required for enhancer selection and function
Natural genetic variation between two mouse strains was used as a natural mutagenesis screen to test various aspects of the proposed model for enhancer selection and function. Chromatin marks H3K4me2, H3K27Ac, and transcription factors PU.1, C/EBPa, and p65 were assessed by ChIP-Seq and GRO-Seq and ...
ORGANISM(S): Mus musculus 
2013-10-15 | E-GEOD-46494 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Adipose tissue from C57BL/6J X C3H/HeJ)F2 and (C3H/HeJ X C57BL/6J )F2
The purpose of this experiment was to determine the expression traits in animals from F2 intercross of inbred strains C57BL/6J, C3H/HeJ. (N=309, 164 males and 145 females). Adipose from 295 F2 female and male mice were generated by intercrossing F1 mice. Mice were fed chow diet containing 4% fat (Ra...
ORGANISM(S): Mus musculus 
2009-08-09 | E-GEOD-11065 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Liver tissue from C57BL/6J X C3H/HeJ)F2 and (C3H/HeJ X C57BL/6J )F2
The purpose of this experiment was to determine the expression traits in animals from F2 intercross of inbred strains C57BL/6J, C3H/HeJ. (N=309, 164 males and 145 females). Liver from 302 F2 female and male mice were generated by intercrossing F1 mice. Mice were fed chow diet containing 4% fat (Rals...
ORGANISM(S): Mus musculus 
2009-08-09 | E-GEOD-11338 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Muscle tissue from C57BL/6J X C3H/HeJ)F2 and (C3H/HeJ X C57BL/6J)F2
The purpose of this experiment was to determine the expression traits in animals from F2 intercross of inbred strains C57BL/6J, C3H/HeJ. (N=309, 164 males and 145 females). Muscle from 285 F2 female and male mice were generated by intercrossing F1 mice. Mice were fed chow diet containing 4% fat (Ral...
ORGANISM(S): Mus musculus 
2009-08-09 | E-GEOD-12795 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Brain tissue from C57BL/6J X C3H/HeJ)F2 and (C3H/HeJ X C57BL/6J)F2
The purpose of this experiment was to determine the expression traits in animals from F2 intercross of inbred strains C57BL/6J, C3H/HeJ. (N=309, 164 males and 145 females). Brain from 292 F2 female and male mice were generated by intercrossing F1 mice. Mice were fed chow diet containing 4% fat (Rals...
ORGANISM(S): Mus musculus 
2009-08-09 | E-GEOD-12798 | biostudies-arrayexpress
UnknownEpigenome-wide association of liver methylation patterns and complex metabolic traits in mice.
Not available
S-EPMC4454894 | biostudies-literature
UnknownEpigenome-wide association in adipose tissue from the METSIM cohort.
Not available
S-EPMC5932563 | biostudies-literature
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