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ProteomicsCyclophilin B function elucidated by electrochemical sensors
We have investigated the function of CypB through negative ionization high resolution LCMS and examined the purity of a CypB protein with intact mass analyzes on a Q Exactive mass spectrometer.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-19 | MSV000089498 | MassIVE
ProteomicsBiotransformation of efavirenz and proteomic analysis of P450s and UGTs in human, mouse, and macaque brain-derived in vitro systems
Antiretroviral drugs such as efavirenz (EFV) are essential to combat HIV infection in the brain, but little is known about how these drugs are metabolized locally. In this study, the cytochrome P450 (P450) and UDP-glucuronosyltransferase (UGT)-dependent metabolism of EFV was probed in brain microsom...
ORGANISM(S): 9606 
2022-10-24 | MSV000090576 | MassIVE
TranscriptomicsMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Xenograft models remain a cornerstone technology in the development of anti-cancer agents. The ability of immunocompromised rodents to support the growth of human tumors provides an invaluable transition between in vitro testing and clinical trials. Therefore, approaches to improve model selection a...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-48433 | biostudies-arrayexpress
ProteomicsAnalysis of nicotinamide based anti-aging supplements in 2024 by untargeted high resolution mass spectrometry
"Anti-aging" supplements purported to contain nicotinamide based compounds were obtained from a variety of sources. Samples were extracted in a solution of 60% methanol at a 1:20 to 1:100 ratio based on pilot tests on solubilization of material. Extracts were clarified by high speed centrifugation, ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-04-20 | MSV000094574 | MassIVE
ProteomicsToward a comprehensive proteomic draft map of the West Virginia Ramp (Allium tricoccum)
Samples of the North American wild ramp (wild leak) Allium tricoccum were harvested during the vegetative and dormant stages of the life cycle. The vegatative plant was cut into root, bulb, stem and leaf sections and homogenized in a bead mill in a solution of 35/35/30 LCMS grade acetonitrile, metha...
ORGANISM(S): Allium Tricoccum (ncbitaxon:138334) 
2024-05-06 | MSV000094686 | MassIVE
UnknownEvaluating cross-hybridization of murine cDNA to the Affymetrix Human Genome U133 Plus 2.0 chipset
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-49353 | biostudies-other
ProteomicsA comparison of acetic and formic acid in single H358 cells analyzed by diaPASEF
Single human H358 cancer cells were isolated by flow cytometry into 96 well plates containing 1 uL of LCMS grade acetonitrile. The cells were placed immediately on dry ice and transported to the lab where they were stored at minus 80C. Dried cell lysate was digested using a solution of 5 nanogram/m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-04-18 | MSV000094565 | MassIVE
TranscriptomicsEvaluating cross-hybridization of murine cDNA to the Affymetrix Human Genome U133 Plus 2.0 chipset
Transcriptomic studies of human tumor xenografts are complicated by the presence of murine cellular mRNA. As such, it is useful to know the extent to which mouse mRNA cross-hybridizes to any given array platform. In this study, murine cDNA samples from diverse sources were hybridized to Affymetrix H...
ORGANISM(S): Mus musculus 
2013-07-31 | E-GEOD-49353 | biostudies-arrayexpress
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