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UnknownHepatic levels of S-adenosylmethionine regulate the adaptive response to fasting.
There has been an intense focus to uncover the molecular mechanisms by which fasting triggers the adaptive cellular responses in the major organs of the body. Here, we show that in mice, hepatic S-adenosylmethionine (SAMe)-the principal methyl donor-acts as a metabolic sensor of nutrition to fine-tu...
S-EPMC10432853 | biostudies-literature
UnknownDynamic cerebral autoregulation is transiently impaired for one week after large-vessel acute ischemic stroke.

Background

Dynamic cerebral autoregulation (DCA) is the continuous counterregulation of cerebral blood flow to fluctuations in blood pressure. DCA can become impaired after acute stroke, but it remains unclear to what extent and over what interval this occurs.

Methods

We included 28 p...
S-EPMC4754197 | biostudies-literature
UnknownGenome-wide association study of long COVID.
Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can result in long coronavirus disease (COVID), typically manifesting a...
S-EPMC12165857 | biostudies-literature
UnknownDifferential Effects of Purinergic Signaling in Gastric Cancer-Derived Cells Through P2Y and P2X Receptors.
Gastric cancer (GC) is the one of the most prevalent cancers and one of the leading causes of cancer-induced deaths. Previously, we found that the expression of purinergic P2Y2 receptor (P2Y2R) is increased in GC samples as compared to adjacent healthy mucosa taken from GC-diagnosed patients. In thi...
S-EPMC6584115 | biostudies-literature
UnknownPharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys.
Genetic inhibition of PI3K signaling increases energy expenditure, protects from obesity and metabolic syndrome, and extends longevity. Here, we show that two pharmacological inhibitors of PI3K, CNIO-PI3Ki and GDC-0941, decrease the adiposity of obese mice without affecting their lean mass. Long-ter...
S-EPMC5867518 | biostudies-literature
UnknownGlycemic variability: prognostic impact on acute ischemic stroke and the impact of corrective treatment for hyperglycemia. The GLIAS-III translational study.

Introduction

Glycemic variability (GV) represents the amplitude of oscillations in glucose levels over time and is associated with higher mortality in critically ill patients. Our aim is to evaluate the impact of GV on acute ischemic stroke (IS) outcomes in humans and explore the impact of t...
S-EPMC7610240 | biostudies-literature
UnknownInfection-driven proteomic signatures in immune cell-derived extracellular vesicles reflect hemorrhagic stroke outcome.
Not available
S-EPMC12822078 | biostudies-literature
UnknownIdentification of a 3'-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Study.

Objective

To investigate the genetic background influencing the development of cardiovascular (CV) disease in patients with rheumatoid arthritis (RA).

Methods

We performed a genome-wide association study (GWAS) in which, after quality control and imputation, a total of 6,308,944 polym...
S-EPMC6590191 | biostudies-literature
UnknownImmune Milieu and Genomic Alterations Set the Triple-Negative Breast Cancer Immunomodulatory Subtype Tumor Behavior.
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous disease. Seven subtypes have been described based on gene expression patterns. Herein, we characterized the tumor biology and clinical behavior of the immunomodulatory (IM) subtype.

Methods

Formalin-fixed paraffin-embedde...
S-EPMC8699570 | biostudies-literature
UnknownThe heterogeneity of reversion to normoglycemia according to prediabetes type is not explained by lifestyle factors.
Healthy lifestyle interventions and drug therapies are proven to have a positive preventative influence on normal glucose regulation in prediabetes. However, little is known on the specific role that these factors play on reversion to normal glycemia according to type of prediabetes. We used data fr...
S-EPMC8102601 | biostudies-literature
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