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ProteomicsCRISPR screening identifies C1orf112 as a novel modulator of the response to ICLs
DNA interstrand crosslinks (ICLs) are highly cytotoxic DNA lesions that are commonly induced by endogenous metabolic processes and chemotherapeutic drugs, such as cisplatin. To prevent detrimental effects associated with ICLs, such as interference with both transcription and replication, cells rely ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-25 | MSV000089544 | MassIVE
ProteomicsThe deubiquitylase Otub1 regulates the chemotactic response in splenic B cells by modulating the stability of the g-subunit Gng2
The ubiquitin (Ub) proteasome system (UPS) performs the covalent attachment of lysine 48-linked poly-Ub chains to substrate proteins, thereby targeting them for degradation, while deubiquitylating enzymes (DUBs) reverse this process. This post-translational modification system regulates many process...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-08 | MSV000091229 | MassIVE
ProteomicsHP1 isoform BioID (Heath et al 2021)
Heath et al (2021) performed proximity based labeling to probe for protein-protein interactions of the HP1 isoforms (alpha, beta, gamma) with and with-out genotoxic stress.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-06-23 | MSV000087687 | MassIVE
UnknownPOGZ promotes homology-directed DNA repair in an HP1-dependent manner
Not available
S-SCDT-EMBOR-2020-51041V1 | biostudies-other
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