Sort   by:  
 Page size 
UnknownHER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer.
Not available
S-EPMC5762201 | biostudies-literature
TranscriptomicsPost-weaning blood transcriptomic differences between Yorkshire pigs divergently selected for residual feed intake
Global gene expression profiles of peripheral blood of 35 to 42 day-old Yorkshire pigs with extremely low (more efficient) and high RFI (less efficient) values from two Iowa State University lines (the low RFI line, n = 15, and the high RFI line, n =16) that were divergently selected for RFI during...
ORGANISM(S): Sus scrofa 
2016-01-15 | E-MTAB-4179 | biostudies-arrayexpress
TranscriptomicsA sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis
Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To identify pathways supporting the Myc oncogenic program, we employed a genome-wide RNAi screen for Myc-synthetic-lethal (MySL) genes and uncovered a role for the SUMO-activating-enzyme (SAE1/2). Loss of SAE1/2 enzyma...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-GEOD-34055 | biostudies-arrayexpress
TranscriptomicsRNA-seq of MYC-Low and MYC-High FC-MYC Cells Following SUMOylation Inhibition with SAEi ML-792
The synthetic lethal relationship between MYC and SAE2 has been previously described in FC-MYC cells using RNAi (Littler et al., 2019). Building on this work, we conducted transcriptomic analysis on MYC-low and MYC-high cells following inhibition of SUMOylation with the SAE1/2 inhibitor, ML-792 (SAE...
ORGANISM(S): Homo sapiens 
2025-04-01 | E-MTAB-14654 | biostudies-arrayexpress
Transcriptomics18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers.
Fluorine-18-fluoro-2-deoxy-D-glucose (FDG) is widely used as positron-emission-tomography (PET) radiotracer for the detection and staging of human cancer. Tumor uptake of FDG varies substantially between different cancer types and between patients with the same tumor type. The molecular basis for th...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-21217 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Xenopus tropicalis oocytes during maturation and early cleavage stages to identify post-transcriptionally regulated Xenopus tropicalis maternal mRNAs
Determine the adenylation state of maternal mRNAs during oocyte maturation and early cleavage stages of the xenopus tropicalis embryos
ORGANISM(S): Xenopus tropicalis 
2007-09-30 | E-MEXP-1236 | biostudies-arrayexpress
GenomicsHot spots of DNA double-strand breaks and genomic contacts of human rDNA units are involved in epigenetic regulation [rDNA units]
4C procedure was used for analysis of genomic contacts of rDNA units in HEK 293T cells. The primers for 4C were selected inside IGS. Our data indicate that mostly rDNA units exhibit close proximity with pericentromeric regions in different chromosomes. We also detected the contacts within a rDNA uni...
ORGANISM(S): Homo sapiens 
2014-10-04 | E-GEOD-49193 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation to identify CUG-BP1/EDEN-BP target mRNAs in Xenopus tropicalis eggs
Identification of RNA bound to the RNA-binding protein CUGBP1/EDENBP in Xenopus tropicalis eggs.
ORGANISM(S): Xenopus tropicalis 
2008-02-21 | E-MEXP-1466 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of macrophages from conventional or antibiotic-treated mice
Antibiotic-treated (ABX) mice exhibit an impaired innate and adaptive antiviral immune response and substantially delayed viral clearance following exposure to systemic LCMV or mucosal influenza virus. Genome-wide transcriptional profiling of macrophages isolated from ABX mice revealed decreased ex...
ORGANISM(S): Mus musculus 
2015-11-05 | E-GEOD-74712 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of naïve bone marrow-resident granulocyte monocyte precursors (GMPs) and TSLP-elicited splenic GMP-like cells
Extramedullary hematopoiesis (EMH) refers to the differentiation of hematopoietic stem cells (HSCs) into effector cells that occurs in compartments outside of the bone marrow. Previous studies linked pattern recognition receptor (PRR)-expressing HSCs, EMH and immune responses to microbial stimuli. H...
ORGANISM(S): Mus musculus 
2014-03-28 | E-GEOD-52485 | biostudies-arrayexpress
Sort   by:  
 Page size