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TranscriptomicsUniform, integration-free iPS cells with a safeguard system using human artificial chromosome vectors
Human artificial chromosomes (HACs) have unique characteristics as gene-delivery vector, e.g., episomal transmission and transfer of multiple, large transgenes. Here, we demonstrate the advantages of HAC vectors for reprogramming mouse embryonic fibroblasts (MEFs) to induced pluripotent stem (iPS) c...
ORGANISM(S): Mus musculus 
2011-10-15 | E-GEOD-29441 | biostudies-arrayexpress
TranscriptomicsThe addition of chromosome 8 leads to characteristic dysregulation of gene expression on all chromosome and transformed-associated phenotypes
To examain effects of trisomy 8 on gene expression in normal human cells, we have employed whole genome microarray expression profiling. To study the effects of aneuploidy in normal human cells, we generated cells which are artificially trisomic chromosome 8 (trisomy 8) using human primary fibroblas...
ORGANISM(S): Homo sapiens 
2011-10-07 | E-GEOD-28076 | biostudies-arrayexpress
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