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UnknownOligosaccharyltransferase (OST) complex inhibition effectively treats rodent and human prions.
Not available
S-EPMC12818742 | biostudies-literature
TranscriptomicsExpression data from CH/LE Mice
We are using genome-wide ChIP-seq with isoform-specific antibodies and chromatin from select tissues of mice challenged with different dietary conditions that enrich for specific SREBPs. We show that hepatic SREBP-2 binds preferentially to two different gene-proximal motifs as well as SREBP-2 dire...
ORGANISM(S): Mus musculus 
2011-03-22 | E-GEOD-28083 | biostudies-arrayexpress
UnknownSite-to-site cross-talk in OST-B glycosylation of hCEACAM1-IgV.
Not available
S-EPMC9618145 | biostudies-literature
TranscriptomicsThe oligosaccharyltransferase complex is an essential component of multiple myeloma plasma cells that regulates bortezomib resistance
Multiple myeloma (MM) is an incurable malignancy characterized by mutated plasma cell clonal expansion in the bone marrow, leading to severe clinical symptoms. Thus, identifying new therapeutic targets for MM is crucial. We identified the oligosaccharyltransferase (OST) complex as a novel vulnerabil...
ORGANISM(S): Homo sapiens 
2025-04-16 | GSE269271 | GEO
UnknownSelenoprotein T is a novel OST subunit that regulates UPR signaling and hormone secretion.
Not available
S-EPMC5666612 | biostudies-literature
UnknownExtreme C-terminal sites are posttranslocationally glycosylated by the STT3B isoform of the OST.
Not available
S-EPMC3613688 | biostudies-literature
TranscriptomicsOligosaccharyl transferase that maintains ER homeostasis enhances immunity via up-regulating p38 MAP kinase signaling in C. elegans
Oligosaccharyl transferase (OST) protein complex mediates the N-linked glycosylation of substrate proteins in the endoplasmic reticulum (ER), which regulates stability, activity and localization of its substrates. Although many OST substrate proteins have been identified, the physiological role of O...
ORGANISM(S): Caenorhabditis elegans 
2020-01-30 | GSE134687 | GEO
GenomicsThe oligosaccharyltransferase complex is an essential component of multiple myeloma plasma cells that regulates bortezomib resistance
The oligosaccharyltransferase complex is an essential component of multiple myeloma plasma cells that regulates bortezomib resistance
PRJNA1120860 | ENA
TranscriptomicsAmino acid deprivation due to overexpression of UCP1 in skeletal muscle: signalling via FGF-21
Recent studies on mouse and human skeletal muscle (SM) demonstrated the important link between mitochondrial function and the cellular metabolic adaptation. To identify key compensatory molecular mechanisms in response to chronic mitochondrial distress, we analyzed mice with ectopic SM respiratory u...
ORGANISM(S): Mus musculus 
2015-02-17 | E-GEOD-45991 | biostudies-arrayexpress
TranscriptomicsshRNA TMEM258 knockdown in HeLa
TMEM258 is associated with the OST complex. Loss of TMEM258 induces ER stress.
ORGANISM(S): Homo sapiens 
2016-11-05 | GSE89542 | GEO
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