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ProteomicsFoxp3+ regulatory T cells control hypothalamic inflammation
The central nervous system (CNS) hypothalamus controls systemic metabolism. Inflammatory CNS processes evolving upon exposure to calorie-rich diet are thought to promote impaired metabolic CNS control, thereby triggering obesity and Type-2 diabetes (T2D). However, immune cells relevant for maintaini...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-20 | PXD004498 | Pride
Hypothalamic inflammation T cells Lc-ms/ms 
TranscriptomicsTranscription profiling of rat metanephric mesenchyme induced to convert into nephron epithelia
During kidney development segmented epithelia of the nephron derive from progenitor cells in the metanephric mesenchyme after induction by secreted molecules from the ureteric bud. We have identified three distinct inductive activities from a ureteric bud cell line. These include leukemia inhibitory...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-5478 | biostudies-arrayexpress
ProteomicsA Stat6/Pten axis links cold exposure with T cell tolerance in adipose tissue
Obesity and type-2 diabetes are associated with tissue-inflammation and metabolic defects in fat depots. Foxp3+regulatory T(Treg) cells mediate T-cell tolerance, thereby controlling tissue inflammation. However, the molecular underpinnings how environmental stimuli interlink T-cell tolerance with ad...
ORGANISM(S): Mus musculus (Mouse) 
2017-09-11 | PXD004671 | Pride
T cell tolerance Foxp3 Cold exposure 
TranscriptomicsHomology-guided Assembly of the Genomes of the Four Diverse Accessions Ler, C24, Bur-0 and Kro-0
Here we present the first whole-genome assemblies of Arabidopsis thaliana strains since the release of the 125 Mb reference genome sequence a decade ago. We demonstrate their practical relevance in studying the expression differences of polymorphic genes and show how the analysis of sRNA sequencing ...
ORGANISM(S): Arabidopsis thaliana 
2011-02-11 | E-GEOD-24569 | biostudies-arrayexpress
TranscriptomicsRNA at 92 M-BM-0C: the non-coding transcriptome of the hyperthermophilic archaeon Pyrococcus abyssi.
The non-coding transcriptome of the hyperthermophilic archaeon Pyrococcus abyssi is investigated using the RNA-seq technology. A dedicated computational pipeline analyzes RNA-seq reads and prior genome annotation to identify small RNAs, untranslated regions of mRNAs, and cis-encoded antisense transc...
ORGANISM(S): Pyrococcus abyssi 
2014-05-31 | E-GEOD-58131 | biostudies-arrayexpress
GenomicsIdentification of a dynamic core transcriptional network in t(8;21) AML regulating differentiation block and self-renewal [ChIP-Seq]
The leukemogenic fusion protein RUNX1/ETO impairs myeloid differentiation and drives malignant self-renewal. Here we use digital footprinting and ChIP-sequencing to identify the core RUNX1/ETO responsive transcriptional network of t(8;21) cells. We show that the transcriptional programme underlying ...
ORGANISM(S): Homo sapiens 
2014-09-24 | E-GEOD-60130 | biostudies-arrayexpress
TranscriptomicsIdentification of a dynamic core transcriptional network in t(8;21) AML regulating differentiation block and self-renewal [RNA-Seq]
The leukemogenic fusion protein RUNX1/ETO impairs myeloid differentiation and drives malignant self-renewal. Here we use digital footprinting and ChIP-sequencing to identify the core RUNX1/ETO responsive transcriptional network of t(8;21) cells. We show that the transcriptional programme underlying ...
ORGANISM(S): Homo sapiens 
2014-09-24 | E-GEOD-54478 | biostudies-arrayexpress
TranscriptomicsArabidopsis defense against Botrytis cinerea: chronology and regulation deciphered by high-resolution temporal transcriptomic analysis (tga3-2 knockout data)
Transcriptional reprogramming forms a major part of a plant's response to pathogen infection. Many individual components and pathways operating during plant defense have been identified but our knowledge of how these different components interact is still rudimentary. We have generated a high-resolu...
ORGANISM(S): Arabidopsis thaliana 
2012-10-03 | E-GEOD-39597 | biostudies-arrayexpress
UnknownRegulatory T cells in the mouse hypothalamus control immune activation and ameliorate metabolic impairments in high-calorie environments.
Not available
S-EPMC11926360 | biostudies-literature
UnknownA Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function.
Not available
S-EPMC5627977 | biostudies-literature
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