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TranscriptomicsTranscription profiling of livers at different time points after partial hepatectomy and at different time points post conception to elucidate gene expression similarities between regenerating and developing liver.
Normal adult liver is uniquely capable of renewal; and repair after injury. Whether this response; represents simple hyperplasia of various liver elements; or requires recapitulation of the genetic program of; the developing liver is not known. To study these possibilities, we examined transcription...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6998 | biostudies-arrayexpress
TranscriptomicsTob1 is a Constitutively Expressed Repressor of Liver Regeneration
How proliferative and inhibitory cell signals integrate to control liver regeneration remains poorly understood. A screen for antiproliferative factors repressed after liver injury identified Tob1, a member of the PC3/BTG1 family of mitoinhibitory molecules as a target for further evaluation. Tob1...
ORGANISM(S): Mus musculus 
2010-05-28 | E-GEOD-21836 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human kidney samples to discover gene signatures of progression and metastasis in renal cell cancer
In order to address the progression, metastasis, and clinical heterogeneity of renal cell cancer (RCC), transcriptional profiling with oligonucleotide microarrays (22,283 genes) was done on 49 RCC tumors, 20 non-RCC renal tumors, and 23 normal kidney samples. Samples were clustered based on gene exp...
ORGANISM(S): Homo sapiens 
2009-04-28 | E-GEOD-15641 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse livers from animals fed a ketogenic diet (KD), a diet high in fat and low in carbohydrates
Analysis of liver gene transcription during feeding of a ketogenic diet. Ketogenic diets may alter physiologic and metabolic profiles in a direction that favors weight loss. C57BL/6J mice were maintained for six weeks on either chow or ketogenic diet. Mice eating KD had lower weights, 90% reduction...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-7699 | biostudies-arrayexpress
TranscriptomicsGenomic Counter-Stress Changes Induced by Mind-Body Practice
Mind-body practices that elicit the relaxation response (RR) have been used worldwide for millennia to prevent and treat disease. The RR is believed to be the counterpart to stress response and is characterized by decreased oxygen consumption, increased exhaled nitric oxide, and reduced psychologica...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-10041 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human oocytes
The identification of genes and deduced pathways from the mature human oocyte can help us better understand oogenesis, folliculogenesis, fertilization, and embryonic development. Human metaphase II oocytes were used within minutes after removal from the ovary, and its transcriptome was compared with...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-12034 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hematopoietic stem cells in the preleukemic phase from wiltype mice and mice deficient in transcription factor PU.1 to identify transcriptional changes preceding malignant transformation
Knockdown of the transcription factor PU.1 (Spi1) leads to acute myeloid leukemia (AML) in mice. We examined the transcriptome of PU.1 knockdown hematopoietic stem cells (HSC) in the preleukemic phase by linear amplification and genome-wide array analysis to identify transcriptional changes precedin...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-5654 | biostudies-arrayexpress
UnknownChemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial.
Not available
S-EPMC3109515 | biostudies-literature
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