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GenomicsThe deubiquitinase Otud7b suppresses cone photoreceptor degeneration in mouse models of retinal degenerative diseases
The deubiquitinase Otud7b suppresses cone photoreceptor degeneration in mouse models of retinal degenerative diseases
PRJNA999717 | ENA
UnknownAtomNet-Aided OTUD7B Inhibitor Discovery and Validation.
Not available
S-EPMC9856706 | biostudies-literature
UnknownOTUD7B is a new deubiquitinase targeting p53.
Not available
S-EPMC11840744 | biostudies-literature
TranscriptomicsThe deubiquitinase Otud7b suppresses cone photoreceptor degeneration in mouse models of retinal degenerative diseases
Primary and secondary cone photoreceptor cell death in retinal degenerative diseases, including age-related macular degeneration and retinitis pigmentosa, leads to severe vision impairment and blindness. Regardless of the fact that protection of cone photoreceptor cells under stress conditions, such...
ORGANISM(S): Mus musculus 
2024-03-12 | GSE239573 | GEO
GenomicsOTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis [RNA-seq]
OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis [RNA-seq]
PRJNA723039 | ENA
GenomicsOTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis [ChIP-seq]
OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis [ChIP-seq]
PRJNA723038 | ENA
UnknownCardiomyocyte-derived OTUD7B promotes cardiac hypertrophy by deubiquitinating SERCA2a.
Not available
S-EPMC12906209 | biostudies-literature
TranscriptomicsOTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis [RNA-seq]
Genomic amplification of OTUD7B is frequently found across human cancers. But its role in tumorigenesis is poorly understood. Lysine‐specific demethylase 1 (LSD1) is known to execute epigenetic regulation by forming corepressor complex with CoREST/histone deacetylases (HDACs). However, the molecular...
ORGANISM(S): Homo sapiens 
2021-04-20 | GSE172370 | GEO
GenomicsOTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis [ChIP-seq]
Genomic amplification of OTUD7B is frequently found across human cancers. But its role in tumorigenesis is poorly understood. Lysine‐specific demethylase 1 (LSD1) is known to execute epigenetic regulation by forming corepressor complex with CoREST/histone deacetylases (HDACs). However, the molecular...
ORGANISM(S): Homo sapiens 
2021-04-20 | GSE172369 | GEO
TranscriptomicsThe deubiquitinase OTUD7B ameliorates central nervous system autoimmunity by inhibiting degradation of glial fibrillary acidic protein and astrocyte hyperinflammation
Astrocytes are central to the pathogenesis of multiple sclerosis; however, their regulation by intrinsic post-translational ubiquitination and deubiquitination is unresolved. This study shows that the deubiquitinating enzyme OTUD7B in astrocytes confers protection against murine experimental autoimm...
ORGANISM(S): Mus musculus 
2025-08-15 | GSE286263 | GEO
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