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TranscriptomicsFoxo1/3-deficient Treg cells
Identification of Foxos target genes in Treg cells. Foxo1and Foxo3 are transcription factors of Foxo family. CD4+Foxp3+ Treg cells isolated from wild-type and Foxo1/3-deficient mice were analyzed by global gene expression profiling. Results indicate Foxos regulate expression of a subset of Treg cell...
ORGANISM(S): Mus musculus 
2010-09-13 | E-GEOD-21678 | biostudies-arrayexpress
GenomicsGenome Wide Mapping of Foxo1 Binding-sites in Murine T Lymphocytes
The Forkhead box O (Foxo) family of transcription factors has a critical role in controlling the development, differentiation, and function of T cells. However, the direct target genes of Foxo transcription factors in T cells have not been well characterized. In this study, we focused on mapping the...
ORGANISM(S): Mus musculus 
2014-08-19 | E-GEOD-60470 | biostudies-arrayexpress
GenomicsNovel Foxo1-dependent Transcriptional Programs Control Treg Cell Function [ChIP-Seq]
Regulatory T (Treg) cells characterized by expression of the transcription factor forkhead box P3 (Foxp3) maintain immune homeostasis by suppressing self-destructive immune responses1-4. Foxp3 operates as a late acting differentiation factor controlling Treg cell homeostasis and function5, whereas ...
ORGANISM(S): Mus musculus 
2012-09-07 | E-GEOD-40656 | biostudies-arrayexpress
TranscriptomicsTranscription Factor Foxo1 Controls Memory CD8+ T Cell Responses To Infection [Affymetrix]
Memory T cells provide immunity against pathogen reinvasion, but mechanisms of their long-term maintenance is unclear. Here we show that mice with the deletion of the transcription factor Foxo1 in activated CD8+ T cells had defective secondary but not primary responses to Listeria monocytogenes inf...
ORGANISM(S): Mus musculus 
2013-05-16 | E-GEOD-46942 | biostudies-arrayexpress
GenomicsTranscription Factor Foxo1 Controls Memory CD8+ T Cell Responses To Infection [ChIP-Seq]
Memory T cells provide immunity against pathogen reinvasion, but mechanisms of their long-term maintenance is unclear. Here we show that mice with the deletion of the transcription factor Foxo1 in activated CD8+ T cells had defective secondary but not primary responses to Listeria monocytogenes inf...
ORGANISM(S): Mus musculus 
2013-05-16 | E-GEOD-46943 | biostudies-arrayexpress
ProteomicsMulti-omics profiling reveals systemic rejuvenation of the aged kidney through senolytic therapy
Cellular senescence is a key driver of kidney aging, leading to functional decline and increased susceptibility to chronic kidney disease. While the senolytic combination of dasatinib and quercetin (D+Q) has shown promise in mitigating age-related pathologies, its long-term effects and underlying mu...
ORGANISM(S): Homo Sapiens 
2026-03-24 | PXD076057 |
TranscriptomicsNovel Foxo1-dependent Transcriptional Programs Control Treg Cell Function [Affymetrix gene expression data]
Regulatory T (Treg) cells characterized by expression of the transcription factor forkhead box P3 (Foxp3) maintain immune homeostasis by suppressing self-destructive immune responses1-4. Foxp3 operates as a late acting differentiation factor controlling Treg cell homeostasis and function5, whereas ...
ORGANISM(S): Mus musculus 
2012-09-07 | E-GEOD-40655 | biostudies-arrayexpress
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