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ProteomicsRe-expression of SMARCA4/BRG1 in Small Cell Carcinoma of Ovary, Hypercalcemic Type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and aggressive form of ovarian cancer. SCCOHT tumors have inactivating mutations in SMARCA4 (BRG1), one of the two mutually exclusive ATPases of the SWI/SNF chromatin remodeling complex. To address the role that BRG1 loss plays...
ORGANISM(S): Homo sapiens (Human) 
2021-01-15 | PXD014134 | Pride
Ovarian carcinoma smarca4 
GenomicsSmall cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4
Small cell carcinoma of the ovary of hypercalcemic type (SCCOHT) is an extremely rare, aggressive cancer affecting children and young women. We identified germline and somatic inactivating mutations in the SWI/SNF chromatin-remodeling gene SMARCA4 in 75% (9/12) of SCCOHT patients in addition to SMAR...
EGAS00001000714 | EGA
UnknownGermline SMARCA4 mutations in patients with ovarian small cell carcinoma of hypercalcemic type.
Not available
S-EPMC4365965 | biostudies-literature
UnknownOvarian carcinoma in children with constitutional mutation of SMARCA4: single-family report and literature review.
Not available
S-EPMC8484133 | biostudies-literature
UnknownDual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.
Not available
S-EPMC4832362 | biostudies-literature
UnknownRecurrent SMARCA4 mutations in small cell carcinoma of the ovary.
Not available
S-EPMC5699446 | biostudies-literature
UnknownClinical utility of SMARCA4 testing by immunohistochemistry in rare ovarian tumours.
Not available
S-EPMC7028983 | biostudies-literature
UnknownSmall cell carcinoma of the ovary hypercalcemic type (SCCOHT): A review and novel case with dual germline SMARCA4 and BRCA2 mutations.
Not available
S-EPMC9554814 | biostudies-literature
UnknownSMARCA4-deficient dedifferentiated ovarian carcinoma with rapid progression during adjuvant platinum-based chemotherapy: a case report and implications for molecular-driven treatment strategies.
Not available
S-EPMC12547099 | biostudies-literature
UnknownSmall cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4.
Not available
S-EPMC4332808 | biostudies-literature
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