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MetabolomicsDistinct metabolic responses of an ovarian cancer stem cell line

Background

Cancer metabolism is emerging as an important focus area in cancer research. However, the in vitro cell culture conditions under which much cellular metabolism research is performed differ drastically from in vivo tumor conditions, which are characterized by variations in the leve...
2021-11-05 | MTBLS150 | MetaboLights
TranscriptomicsTranscriptional profile of carcinoma-stem-like cells (CSC) extracted from a primary ovarian cancer cell line
A population of non-adherent cells with stem-like characteristics (OVA-BS4 spheres) has been isolated from a primary human epithelial ovarian cancer (EOC) cell line (OVA-BS4) under selective conditions. OVA-BS4 spheres were characterized for their pharmacological properties and their molecular profi...
ORGANISM(S): Homo sapiens 
2018-01-15 | E-MTAB-4799 | biostudies-arrayexpress
TranscriptomicsOvarian Cancer Cell line Panel (OCCP): gene expression data.
Epithelial ovarian cancer is a very heterogeneous disease and remains the most lethal gynaecological malignancy in the Western world. Rational therapeutic approaches need to account for interpatient and intratumoral heterogeneity in treatment design. Detailed characterization of in vitro models repr...
ORGANISM(S): Homo sapiens 
2014-09-18 | E-GEOD-53418 | biostudies-arrayexpress
ProteomicsIn-depth proteomic analyses of ovarian cancer cell line exosomes reveals differential enrichment of functional categories compared to the NCI 60 proteome.
Molecular communication between cancer cells and its stromal microenvironment is a key factor for cancer progression. Alongside classic secretory pathways, it has recently been proposed that small membranous vesicles are alternative mediators of intercellular communication. Exosomes carry an effecto...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-23 | MSV000080278 | MassIVE
TranscriptomicsExpression data from Versican (VCAN) protein treated ovarian cancer cell line OVCA433
Advanced ovarian cancer is the most lethal gynecologic malignancy in the United States. Currently patients are treated by surgical cytoreductive surgery with the aim of reducing tumor burden to microscopic disease followed by adjuvant combined treatment with a platinum and taxane containing chemothe...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-40241 | biostudies-arrayexpress
TranscriptomicsGene expression profiling after RNA interference of CXCR4 in human ovarian cancer cell line IGROV-1.
In the past three years the role of inflammatory cytokines and chemokines in tumour promotion and progression has been intensively studied. The chemokine receptor CXCR4 and its ligand CXCL12 are commonly expressed in malignant cells from primary tumours, metastases and also in malignant cell lines. ...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-13763 | biostudies-arrayexpress
TranscriptomicsClaudin-7 is frequently overexpressed in ovarian cancer and promotes invasion
Claudins are tight junction proteins that are involved in tight junction formation and function. Previous studies have shown that claudin-7 is frequently upregulated in epithelial ovarian cancer (EOC) along with claudin-3 and claudin-4. Here, we investigate in detail the expression patterns of claud...
ORGANISM(S): Homo sapiens 
2012-09-19 | E-GEOD-26055 | biostudies-arrayexpress
ProteomicsIntegrative proteomic profiling of ovarian cancer cell lines reveals precursor-cell associated proteins and functional status
A cell line representative of human high-grade serous ovarian cancer (HGSOC) should not only resemble its tumor of origin at the molecular level, but also demonstrate functional utility in pre-clinical investigations. Here we report the integrated proteomic analysis of 26 ovarian cancer cell lines, ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-30 | MSV000080814 | MassIVE
MetabolomicsOVCAR-3 spheroid-derived cells display distinct metabolic profiles
Recently, multicellular spheroids were isolated from a well-established epithelial ovarian cancer cell line, OVCAR-3, and were propagated in vitro. These spheroid derived cells displayed numerous hallmarks of cancer stem cells, which are chemo and radioresistant cells thought to be a significant cau...
2015-01-08 | MTBLS152 | MetaboLights
TranscriptomicsIdentification of Novel Therapeutic Targets in Microdissected Clear Cell Ovarian Cancers
To identify the gene signature accounting for the distinct clinical outcomes in ovarian clear cell cancer patients Clear cell ovarian cancer is an epithelial ovarian cancer histotype that is less responsive to chemotherapy and carries poorer prognosis than serous and endometrioid histotypes. Despite...
ORGANISM(S): Homo sapiens 
2011-05-24 | E-GEOD-29450 | biostudies-arrayexpress
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