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MetabolomicsProfiling the metabolome of uterine fluid for early detection of ovarian cancer

Ovarian cancer (OC) causes high mortality in women because of ineffective biomarkers for early diagnosis. Here, we perform metabolomics analysis on an initial training set of uterine fluid from 96 gynecological patients. A seven-metabolite-marker panel consisting of vanillylmandelic acid, norepin...

2023-03-06 | MTBLS4861 | MetaboLights
MetabolomicsUHPLC-OE-MS metabolic profile of follicular fluid in patients with ovarian endometriosis: a pilot study of an endometriosis cohort

BACKGROUND: Endometriosis is a common benign gynaecological disorder. A number of studies have confirmed that the occurrence of disease in endometriosis patients is associated with metabolic changes in biological fluids and tissues. We set out to investigate the metabolic charact...

2024-02-20 | MTBLS8621 | MetaboLights
MetabolomicsSphingosine-1-phosphate receptor 1 promotes ovarian cancer tumorsphere proliferation and metastasis
Despite extensive clinical endeavors to enhance high-grade serous ovarian cancer (HGSOC) detection and treatment, an alarming half of diagnosed women succumb annually to this disease. Significantly, nearly all HGSOC cases manifest ascites at diagnosis, a poor prognostic indicator. Malignant ascites ...
2026-03-04 | MTBLS13770 | MetaboLights
MetabolomicsAmniotic-fluid metabolomics identifies phospholipid remodeling as a metabolic signature of intrauterine exposure in pregnancies with polycystic ovary syndrome
Background: Polycystic ovary syndrome is associated with metabolic and hormonal disturbances during pregnancy, but whether these alterations are reflected in the fetal intrauterine exposure environment remains incompletely understood. This study aimed to identify polycystic ovary syndrome-related in...
2026-07-25 | MTBLS14946 | MetaboLights
MetabolomicsAndrogens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome-GC-MS analysis of follicular fluid
Polycystic ovary syndrome (PCOS) is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression of PCOS. However, the underlying mechanism remains unclear. In this study, we conducted targeted me...
2025-04-14 | MTBLS12371 | MetaboLights
MetabolomicsResolvin E1 in follicular fluid acts as a potential biomarker and improves oocyte developmental competence by optimizing cumulus cells

The metabolic profile of follicular fluid (FF) has been investigated to look for biomarkers for oocyte quality. Resolvin E1 (RvE1), a potent pro-resolving mediator, was reported to have protective action in cell function. The study aimed to examine the predictive value of RvE1 for oocyte quality ...

2020-03-26 | MTBLS1488 | MetaboLights
TranscriptomicsA platform of patient-derived tumor xenografts (EOC-xenografts) to recapitulate the clinicopathology and genetic alterations of ovarian cancer
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. On the basis of its histopathology and molecular-genomic changes ovarian cancer has been divided into subtypes, each with distinct biology and outcome. The aim of this study was to develop a panel of patient-derived EOC-xen...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-56920 | biostudies-arrayexpress
ProteomicsProteome profiling of ovarian cancer and cirrhosis ascites
Proteome-metabolome profiling of ovarian cancer ascites reveals novel components involved in intercellular communication http://www.mcponline.org/content/early/2014/09/30/mcp.M114.041194.full.pdf+html?sid=78e7a955-fa54-4ded-b296-89f1fb6adbec
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079934 | MassIVE
TranscriptomicsAscites enriches for ovarian cancer stem-like cells that express membrane GRP78
Ovarian cancer patients are generally diagnosed at stage III/IV, when ascites is common. The volume of ascites positively correlates with the extent of metastasis and negatively with prognosis. Membrane GRP78, a stress-inducible endoplasmic reticulum chaperone which also appears on the plasma membra...
ORGANISM(S): Mus musculus 
2015-03-09 | E-GEOD-61285 | biostudies-arrayexpress
ProteomicsOvarian fluid proteome variation associates with sperm swimming speed in an externally fertilizing fish
Ovarian fluid was collected from 6 adult female Chinook salmon during their annual spawning run. Two replicates were analyzed for each ovarian fluid sample fraction using 80 and 100 minute gradients, respectively. Protein abundances were estimated using iTRAQ.
ORGANISM(S): Oncorhynchus tshawytscha 
2021-04-17 | PXD014551 | Pride
Oncorhynchus tshawytscha Chinook salmon Ovarian fluid Coelomic fluid Itraq 
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