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TranscriptomicsExpression data from human cumulus cells isolated from oocytes at MI and MII stages in polycystic ovary syndrome (PCOS) patients
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that is characterized by increased circulating androgen levels, anovulatory infertility, and frequently, insulin resistance and hyperinsulinemia.The abnormity of oocyte nuclear maturity is the main reason for anovulatory i...
ORGANISM(S): Homo sapiens 
2013-06-05 | E-GEOD-40400 | biostudies-arrayexpress
GenomicsSimilarity and diversity of the tumor microenvironment in multiple metastases: critical implications for overall and progression-free survival of high-grade serous ovarian cancer.
The tumor microenvironment is pivotal in influencing cancer progression and metastasis. Different cells co-exist with high spatial diversity within a patient, yet their combinatorial effects are poorly understood. We investigate the similarity of the tumor microenvironment of 192 local metastatic le...
EGAS00001002065 | EGA
TranscriptomicsExpression data from mouse ALDH1 positive and ALDH1 negative ovarian surface epithelium (OSE) cells
The hilum region of the mouse ovary, the transitional/junction area between OSE, mesothelium and tubal (oviductal) epithelium is identified as a previously unrecognized stem cell niche of the OSE. OSE cells with high ALDH1 activity have been predominantly detected in the hilum region by immunohistoc...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43897 | biostudies-arrayexpress
ProteomicsProteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature
The ovarian microenvironment becomes fibrotic and stiff with age due in part to increased stromal collagen and decreased hyaluronan. However, the extracellular matrix (ECM) is a complex network of hundreds of proteins, glycoproteins and glycans which are highly tissue specific and undergo pronounced...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-04-24 | MSV000091790 | MassIVE
TranscriptomicsDeregulation of PPAR-beta/delta target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment - RNAseq
The transcriptome of serous ovarian cancer tumor associated macrophages was characterized. Additionally, their transcription response to PPARD agonists and inverse agonists in cell culture was analyzed.
ORGANISM(S): Homo sapiens 
2015-05-31 | E-MTAB-3167 | biostudies-arrayexpress
GenomicsDeregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment - ChIPseq
PPARD and RXR genome wide binding in tumor associated macrophages from serous ovarian carcinoma was characterized.
ORGANISM(S): Homo sapiens 
2015-06-01 | E-MTAB-3166 | biostudies-arrayexpress
TranscriptomicsExpression data from TGF-beta-treated human ovarian fibroblasts
Advanced ovarian cancer is the most lethal gynecologic malignancy in the United States. Ovarian cancer cells are known to have diminished response to TGF-beta, but it remains unclear whether TGF-beta can modulate ovarian cancer cell growth in an indirect manner through cancer-associated fibroblasts ...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-40266 | biostudies-arrayexpress
ProteomicsUnveiling Multi-Omics and Immune Landscapes in COVID-19 Patients' Ovaries Microenvironment for Oocyte Competency Biomarkers Identification
Background: The outbreak of coronavirus disease 2019 (COVID-19) poses a considerable health threat to humanity, with potential implications for the ovarian microenvironment remaining uncertain. Methods: Transcriptomic and proteomic analyses of ovarian granulosa cells, along with metabolomic and lipi...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058234 | Pride
Covid-19 Immune landscapes Proteomics Ovary microenvironment 
GenomicsSingle-cell atlas of mandarin fish ovary reveals the trajectories of oogenesis and its immune microenvironment development in teleosts
Single-cell atlas of mandarin fish ovary reveals the trajectories of oogenesis and its immune microenvironment development in teleosts
PRJNA1269506 | ENA
TranscriptomicsTesticular germ cell tumour cells release microRNA containing extracellular vesicles that induce phenotypic and genotypic changes in cells of the tumour microenvironment
Malignant germ-cell-tumours (GCTs) are characterised by microRNA (miRNA/miR-) dysregulation, with universal over-expression of miR-371~373 and miR-302/367 clusters regardless of patient age, tumour site, or subtype (seminoma/yolk-sac-tumour/embryonal carcinoma). These miRNAs are released into the bl...
ORGANISM(S): Homo sapiens 
2023-09-30 | E-MTAB-13322 | biostudies-arrayexpress
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