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ProteomicsSubstrate profiling of the metalloproteinase ovastacin – Implications for its physiological function in mammalian fertilization
The metalloproteinase ovastacin is released by the mammalian oocyte upon fertilization and cleaves zona pellucida protein 2, a component of the surrounding extracellular matrix, at a distinct cleavage site. This limited proteolysis hardens the zona pellucida, abolishes sperm binding and thereby regu...
ORGANISM(S): Mus Musculus (mouse) 
2023-09-15 | PXD038561 | JPOST Repository
UnknownIntracellular activation of ovastacin mediates pre-fertilization hardening of the zona pellucida.
Not available
S-EPMC5909858 | biostudies-literature
UnknownOvastacin: An oolemma protein that cleaves the zona pellucida to prevent polyspermy.
Not available
S-EPMC10477413 | biostudies-literature
UnknownMammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases.
Not available
S-EPMC6346019 | biostudies-literature
UnknownA Primary Evaluation of Potential Small-Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Treatment.
Not available
S-EPMC7496240 | biostudies-literature
UnknownHeteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold-Hopping Approach.
Not available
S-EPMC8048867 | biostudies-literature
UnknownMembrane associated cancer-oocyte neoantigen SAS1B/ovastacin is a candidate immunotherapeutic target for uterine tumors.
Not available
S-EPMC4745790 | biostudies-literature
UnknownSAS1B protein [ovastacin] shows temporal and spatial restriction to oocytes in several eutherian orders and initiates translation at the primary to secondary follicle transition.
Not available
S-EPMC4091973 | biostudies-literature
UnknownThe E-modulus of the oocyte is a non-destructive measure of zona pellucida hardening.
Not available
S-EPMC8494380 | biostudies-literature
UnknownGlycan-Independent Gamete Recognition Triggers Egg Zinc Sparks and ZP2 Cleavage to Prevent Polyspermy.
Not available
S-EPMC6549238 | biostudies-literature
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