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MetabolomicsMulti-omics analysis identifies a microbiota–bile acid–TLR signaling axis driving bladder injury in interstitial cystitis

Hunner-type interstitial cystitis/bladder pain syndrome (HIC) is a complex and clinically challenging chronic disorder characterized by bladder-centered symptoms, including persistent pelvic pain and urinary urgency frequency, with elusive pathogenesis involving poorly defined multi-system intera...

2025-12-16 | MTBLS13513 | MetaboLights
MetabolomicsMulti-omics analysis identifies a microbiota–bile acid–TLR signaling axis driving bladder injury in interstitial cystitis

Hunner-type interstitial cystitis/bladder pain syndrome (HIC) is a complex and clinically challenging chronic disorder characterized by bladder-centered symptoms, including persistent pelvic pain and urinary urgency frequency, with elusive pathogenesis involving poorly defined mult...

2025-12-16 | MTBLS13512 | MetaboLights
ProteomicsRat-bladder-OAB - Proteomic analysis of urothelium of rats with detrusor overactivity induced by bladder outlet obstruction
Overactive bladder (OAB) syndrome is a condition that has four symptoms: urgency, urinary frequency, nocturia, and urge incontinence and negatively affects a patient’s life. Recently, it is considered that the urinary bladder urothelium is closely linked to pathogenesis of OAB. However, the mechanis...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-02-09 | PXD007571 | Pride
Oab Rat Bladder outlet obstruction Bladder 
ProteomicsHuman urine proteome in overactive bladder syndorme
The aim of this study is analysis of urinary proteomic pattern in healthy people and patients suffering from OAB symptoms by means of mass spectrophotometry. Establishing characteristic protein profiles, qualitative and quantitative, for OAB will help to define specific protein marker and will allow...
ORGANISM(S): Homo sapiens (Human) 
2020-05-12 | PXD017799 | Pride
Urgency urinary incontinence  lower urinary tract symptoms Overactive bladder 
TranscriptomicsExpression data from mouse whole bladders of cyclophosphamide-induced cystitis
To analyze the gene expression of non-bacterial bladdder inflammation, mouse cyclophosphamide(CYP)-induced model of cystitis was adapted. Forty-eight hour after CYP or vehicle treatment, total RNA was extracted from CYP-treated group (CYP150) and control group (CYP0). We used microarrays to detail t...
ORGANISM(S): Mus musculus 
2014-03-18 | E-GEOD-55986 | biostudies-arrayexpress
UnknownReduction of Overactive Bladder Medications in Spinal Cord Injury With Self-Administered Neuromodulation: A Randomized Trial.
Not available
S-EPMC11560598 | biostudies-literature
Genomics
Urinary microbiome of patients with overactive bladder
PRJNA970190 | ENA
UnknownBeyond the bladder: poor sleep in women with overactive bladder syndrome.
Not available
S-EPMC7263944 | biostudies-literature
UnknownAssociation between Menopausal Symptoms and Overactive Bladder: A Cross-Sectional Questionnaire Survey in China.
Not available
S-EPMC4598107 | biostudies-literature
UnknownRisk factors associated with the progression of overactive bladder among patients with type 2 diabetes.
Not available
S-EPMC6851595 | biostudies-literature
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