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MetabolomicsTo explore the role of circulating oxidized lipids in the progression and prognosis of SA-AKI by means of histochemistry

Background: Plasma oxidized lipids are intimately linked to immune regulation as bioactive mediators. However, it is not clear whether they are related to the progression of sepsis-associated acute kidney injury (SA-AKI) and the effect of continuous renal replacement therapy (CRR...

2024-12-16 | MTBLS11695 | MetaboLights
MetabolomicsNGT induced mitochondrial dysfunction, led to apoptosis, and changed metabolites associated with oxidized lipids in sperm of Pacific oyster (Crassostrea gigas).

The risk of norgestrel (NGT) exposure in the aquatic environment has been identified, but the toxic effects on invertebrate germ cells are unknown. Therefore, the toxic effects of NGT on oyster sperm were investigated by combining transcriptome and metabolome analysis with histology. Transcriptom...

2025-07-05 | MTBLS12685 | MetaboLights
ProteomicsUVA and to UV-oxidized lipids proteomic regulation of the human keratinocytes
Ultraviolet light is the dominant environmental oxidative skin stressor and a major skin aging factor. We studied which oxidized phospholipid (OxPL) mediators Ultraviolet A (UVA) would generate in primary human keratinocytes (KC). Mass spectrometric analysis of the oxidized phospholipidome of KC imm...
ORGANISM(S): Homo sapiens (Human) 
2019-05-27 | PXD008050 | Pride
Uv Keratinocytes Oxidized lipids Human 
TranscriptomicsTranscription profiling of UV- or oxidized lipid treated dermal skin fibroblasts
Long wavelength Ultraviolet (UVA-1) radiation causes oxidative stress that leads to the formation of noxious substances within the skin. As a defensive mechanism skin cells produce detoxifying enzymes and antioxidants when they detect modified molecules. We have recently shown that UVA-1 irradiation...
ORGANISM(S): Homo sapiens 
2009-11-10 | E-GEOD-13606 | biostudies-arrayexpress
OtherEpilipidomics platform for holistic profiling of oxidized complex lipids in blood plasma of obese individuals
Raw files corresponding to the epilipidomic dataset for identification and relative quantification of oxidized complex lipids in the blood plasma of lean and obese individuals.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-23 | MSV000088608 | MassIVE
TranscriptomicsTranscription profiling of macrophages from Familial Hypercholesterolemia(FH) patients with tendon xanthomas (TX+) and without tendon xanthomas (TX-) to evaluate the gene expression profile in presence and absence of oxidized LDL
Total RNA pools from macrophages from Familial Hypercholesterolemia(FH) patients with tendon xanthomas (TX+) and without tendon xanthomas (TX-) were analyzed using Affymetrix oligonucleotide arrays (HGU133A) to evaluate the gene expression profile in presence and absence of oxidized LDL.
ORGANISM(S): Homo sapiens 
2006-01-01 | E-MEXP-360 | biostudies-arrayexpress
MetabolomicsGNPS Epilipidomics platform for holistic profiling of oxidized complex lipids in blood plasma of obese individuals
Raw files corresponding to the epilipidomic dataset for identification and relative quantification of oxidized complex lipids in the blood plasma of lean and obese individuals.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-23 | MSV000088608 | GNPS
TranscriptomicsIdentification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids
Oxidized phospholipids are thought to promote atherogenesis by stimulating endothelial cells (ECs) to produce inflammatory cytokines, such as IL-8. In studies with mouse models, we previously demonstrated that genetic variation in inflammatory responses of endothelial cells to oxidized lipids contri...
ORGANISM(S): Homo sapiens 
2011-06-13 | E-GEOD-29903 | biostudies-arrayexpress
GenomicsOxidized Lipids and CD36-Mediated Lipid Peroxidation in CD8 T Cells Suppress Anti-Tumor Immune Responses
Oxidized Lipids and CD36-Mediated Lipid Peroxidation in CD8 T Cells Suppress Anti-Tumor Immune Responses
PRJNA718612 | ENA
OtherEpilipidomics profiling of oxidized lipids DHCR7
relative quantification of oxidized lipids in human cell line (fibrosacroma) using parallel reaction monitoring
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-08-11 | MSV000090108 | MassIVE
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