Oxidosqualene synthase

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Unknown (63)
Transcriptomics (15)
Genomics (7)
Proteomics (5)
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Organisms

Drosophila melanogaster (13)
Homo sapiens (6)
Osmerus mordax (1)
Bombyx mori (1)
Oryzias latipes (1)
Arabidopsis thaliana (1)
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EFO:0001352 (1)
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Human immunodeficiency virus 1 (1)
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Repository

biostudies-arrayexpress (18)
jPOST (3)
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MassIVE (1)
MetaboLights (1)
pride (1)

Technology Type

Mass spectrometry (1)
Mass Spectrometry (1)
Shotgun proteomics (1)

Instrument Platform

PromethION (1)
GridION (1)
Orbitrap Fusion Lumos (1)
Liquid Chromatography MS - positive - reverse phase (1)
Liquid Chromatography MS - negative - reverse phase (1)

Publication Date

2013 (5)
2014 (4)
2015 (3)
2019 (3)
2012 (2)
2010 (2)
2026 (1)
2016 (1)
2023 (1)
2024 (1)
2021 (1)

Metabolite Name

Furost-5-en-3,22,26-triol-3,26-di-O-glucoside (Lilioglycoside K) (1)
Spirost-5-en-3-ol-3-O-glucosyl(1?2)[glucosyl(1?3)]glucosyl(1?4)galactoside (1)
N-Deacetyl colchicine (1)
26-O-?-D-glucopyranose Radical-(25R)-?5(6)-ene-16,22-diketone-furostane-3?,26-diol-3-O-?-L-rhamnosyl-(1?2)-O-?-D-glucopyranoside (1)
Isoorientin-7-O-(6''-feruloyl)glucoside (1)
27-Hydroxyspirost-5-en-3-yl-O-rhamnosyl-(1?2)-O-[glucosyl-(1?6)]-glucoside (1)
26-O-?-D-Glucopyranosyl-furost-5,20-diene-3?,26-diol-3-O-[?-L-rhamnopyranosyl (1)
Furost-5-en-3,22,26-triol-3-O-rhamnosyl(1?3)[arabinosyl(1?4)]glucoside-26-O-glucoside (Polyphyllin H)* (1)
Isorhamnetin-3-O-(2''-O-glucosyl)galactoside-7-O-glucoside (1)
6-Hydroxy-spirost-4-ene-3-yl-rhamnosyl(1?4)[rhamnosyl(1?2)]glucoside (Polyphylloside A) (1)
Diosgenin-3-O-glucosyl(1?2)glucosyl(1?4)galactoside (Funkioside D)* (1)
26-O-?-D-glucopyranosyl-(25R)-?5(6),16(17),20(22)-triene-furostane-3?,26-diol-3-O-?-L-rhamnosyl-(1?2)-O-?-D-glucopyranoside (1)
?-Guanidinovaleric acid (1)
24-Hydroxypennogenin-3-O-rhamnosyl(1?2)xyloyl(1?4)glucoside (1)
3-hydroxy-20-ene-Furostanol (1)
Disoseptemloside D (1)
Diosgenin-3-O-rhamnosyl(1?2)[xylosyl(1?3)]fucoside (Ophiopogonin D; LS-10)* (1)
Spirost-5,14-diene-3-ol-3-O-{glucosyl(1?2)[xylosyl(1?3)]glucosyl(1?4)}galactoside (1)
27-O-Glucosyl-spirost-5-en-3,17,27-triol-3-O-rhamnosyl(1?2)[rhamnosyl(1?4)rhamnosyl(1?4)]glucoside (Parisverticoside C) (1)
Diosgenin-3-O-rhamnosyl(1?4)rhamnosyl(1?2)glucoside (1)
Spirost-5-en-3-ol-3-O-glucosyl(1?3)[fucosyl(1?2)]glucosyl(1?4)galactoside (1)
26-O-Glucosyl-nuatigenin-3-O-glucoside* (1)
8-Hydro-4,7-dimethoxyfuranaquinoline (1)
Pavitnoside D (1)
Spirost-5-en-12-one-3-O-glucosyl(1?2)glucosyl(1?4)galactoside (Pratioside D1) (1)
Quercetagetin; 3,3',4',5,6,7-Hexahydroxyflavone (1)
26-O-Glucosyl-3,20,26-trihydroxyfurostan-5,22-diene-3-O-rhamnosyl(1?4)rhamnosyl(1?4)rhamnosyl(1?4)glucoside (Padelaoside C)* (1)
Cimicifugic acid A-Diglucose (1)
Caffeoylspermidine (1)
Furost-20(22)-en-3,26-diol-3-O-glucosyl(1?2)galactoside-26-O-glucoside (Timosaponin B-III,Anemarrhenasaponin IV,Pseudoprototimosaponin A-III)* (1)

Study type

Other (4)
RNA-seq of coding RNA (4)
RNA-seq of non coding RNA (4)
Transcription profiling by array (3)
ChIP-seq (2)
DNA-seq (1)

Release Date

2013 (8)
2023 (8)
2022 (8)
2014 (7)
2017 (7)
2016 (5)
2015 (5)
2020 (5)
2021 (4)
2018 (4)
2010 (3)
2025 (3)
2024 (3)
2008 (3)
2012 (2)
2019 (2)
2026 (1)
2009 (1)
2004 (1)
1995 (1)

Lab affiliation

Mode of Action group, University of Dundee (1)

First Public Date

2024 (1)
2021 (1)

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Plant oxidosqualene metabolism: cycloartenol synthase-dependent sterol biosynthesis in Nicotiana benthamiana.

Not available

S-EPMC4208727 | biostudies-literature

Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by activating a shunt pathway that generates the toxic metabolite 24(S),25-epoxycholesterol

LUM2_708738 - MM0299-probe bound protein; LUM2_708739 - MM0299 competition; LUM2_850369 - Ro-alkyne bound protein; LUM2_850370 - Ro 48-8071 competition

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

2023-01-11 | MSV000091046 | MassIVE

An Unexpected Oxidosqualene Cyclase Active Site Architecture in the Iris tectorum Multifunctional α-Amyrin Synthase.

Not available

S-EPMC8297885 | biostudies-literature

Identification and Functional Characterization of Oxidosqualene Cyclases from Medicinal Plant Hoodia gordonii.

Not available

S-EPMC10818575 | biostudies-literature

Molecular characterization and differential expression studies of an oxidosqualene cyclase (OSC) gene of Brahmi (Bacopa monniera).

Not available

S-EPMC3781283 | biostudies-literature

Molecular cloning, characterization, and functional expression of rat oxidosqualene cyclase cDNA.

Not available

S-EPMC40967 | biostudies-literature

Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial

Samples were reduced by the addition of TCEP (25 mM final concentration) and incubated at 37 ºC for 10 min. Alkylation was carried out by the addition of iodoacetamide (25 mM final concentration) and incubated at RT for 1 h in the dark. Samples were then digested by the addition of 1:50 LysC (Wako, ...

ORGANISM(S): Leishmania donovani BPK282A1

2021-07-18 | PXD023780 | Pride