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GenomicsA study of the effect of OxLDL on C/EBP beta binding in human macrophages using chromatin immunoprecipitation for C/EBP beta with high throughput sequencing (ChIP-seq)
We report the C/EBP beta transcription factor binding landscape in human macrophages and oxLDL-induced foam cells ChIP-seq for C/EBP beta binding was performed in human macrophages and oxLDL induced-foam cells with quadruple biological replicates
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-66192 | biostudies-arrayexpress
TranscriptomicsHuman endothelial gene expression under estradiol and oxLDL treatments
DNA microarrays were used to investigate global gene expression patterns in cultured human umbilical artery endothelial cells (HUAECs) exposed to 1 nmol/L estradiol and/or 100 µg/ml oxidized low density lipoprotein (oxLDL) for 24 hours compared to control cells. HUAECs from 15 separate cultures were...
ORGANISM(S): Homo sapiens 
2011-06-10 | E-GEOD-29881 | biostudies-arrayexpress
TranscriptomicsGene expression in primary human macrophages and foam cells
The aim of the experiment was to determine the effects of 48 hours of treatment with oxidized low density lipoprotein (oxLDL) on gene expression in primary human monocyte-derived macrophages. 6 independent biological replicates were processed. From each replicate half of the cells were treated with ...
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-54666 | biostudies-arrayexpress
Genomicsmonocyte reprogramming by oxLDL
monocyte reprogramming by oxLDL
PRJNA975552 | ENA
GenomicsChromatin immunoprecipitation with next generation sequencing (ChIP-seq) of H3K27ac in primary human macrophages and foam cells
We report the enhancer landscape in primary human macrophages and foam cells using ChIP-seq for the H3K27ac histone mark CD14+ monocytes were isolated from the blood of 2 healthy male volunteers. Monocytes were differentiated into macrophages by culture for 7 days with 50ng/ml macrophage colony stim...
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-54972 | biostudies-arrayexpress
GenomicsFormaldehyde-assisted isolation of regulatory elements with next generation sequencing (FAIRE-seq) in primary human macrophages and foam cells
We report the open chromatin landscape in primary human macrophages and foam cells using FAIRE-seq CD14+ monocytes were isolated from the blood of 3 healthy volunteers. Monocytes were differentiated into macrophages by culture for 7 days with 50ng/ml macrophage colony stimulating factor and then tre...
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-54971 | biostudies-arrayexpress
TranscriptomicsTranscriptional study of oxLDL-induced foam cell formation in WT and Atf3-/- murine bone marrow macrophages
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-loaded macrophages in the arterial wall. Intimal macrophages internalize modified lipoproteins such as oxidized LDL (oxLDL) through scavenger receptors, leading to storage of excess cholesteryl esters in lip...
ORGANISM(S): Mus musculus 
2012-03-23 | E-GEOD-32358 | biostudies-arrayexpress
GenomicsTranscriptomes of oxLDL exposed trained monocytes
Transcriptomes of oxLDL exposed trained monocytes
PRJNA504431 | ENA
GenomicsEpigenomes of oxLDL exposed trained monocytes
Epigenomes of oxLDL exposed trained monocytes
PRJNA504432 | ENA
TranscriptomicsMonocyte to macrophage differentiation and loading/deloading with lipoproteins (eLDL, oxLDL, HDL3)
Elutriated monocytes from 9 healthy donors with ApoE3/E3 genotype were differentiated for up to six days in vitro to macrophages using rhMCSF under serum-free conditions. Samples were taken on days 1, 4, 5 and 6 and analyzed for their transcriptomic profiles. After four days of differentiation cells...
ORGANISM(S): Homo sapiens 
2014-03-02 | E-MTAB-2298 | biostudies-arrayexpress
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