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MetabolomicsFood Deprivation Enhances Disease Resistance: Underlying Mechanisms in Oysters Confronted with Pacific Oyster Mortality Syndrome

Variation in food availability can shape host susceptibility and pathogen virulence, thereby impacting disease outcomes. An ad libitum diet may enhance host physiology and immunity but it can also favor pathogen proliferation. Here, we investigated how food availability (ad libitum vs. starvation...

2025-11-14 | MTBLS13313 | MetaboLights
MetabolomicsNGT induced mitochondrial dysfunction, led to apoptosis, and changed metabolites associated with oxidized lipids in sperm of Pacific oyster (Crassostrea gigas).

The risk of norgestrel (NGT) exposure in the aquatic environment has been identified, but the toxic effects on invertebrate germ cells are unknown. Therefore, the toxic effects of NGT on oyster sperm were investigated by combining transcriptome and metabolome analysis with histology. Transcriptom...

2025-07-05 | MTBLS12685 | MetaboLights
TranscriptomicsWhole transcriptome profiling of successful immune response to Vibrio infections in the oyster Crassostrea gigas by digital gene expression analysis
The cultivated Pacific oyster Crassostrea gigas has suffered for decades large scale summer mortality phenomenon resulting from the interaction between the environment parameters, the oyster physiological and/or genetic status and the presence of pathogenic microorganisms including Vibrio species. T...
ORGANISM(S): Crassostrea gigas 
2011-11-01 | E-GEOD-33390 | biostudies-arrayexpress
MetabolomicsUnravelling age-driven molecular transitions underlying Pacific Oyster Mortality Syndrome permissiveness in Magallana gigas

Ageing is a progressive and irreversible biological process characterized by the deterioration of physiological functions and increased vulnerability to mortality. Although extensively studied in vertebrates, ageing in long-lived invertebrates remains comparatively unexplored. While ageing typica...

2025-12-08 | MTBLS13463 | MetaboLights
MetabolomicsNorgestrel exposure accelerated the abnormal occurrence of germinal vesicle breakdown and triggered damage to cellular structure and function in oocytes of the Pacific oyster (Crassostrea gigas)

Progestins are ubiquitous in aquatic environments, with adverse effects on aquatic organisms' reproduction even at extremely low concentrations (0.8 ng/L). As female germ cells, oocytes play an irreplaceable role in organismal reproductive processes. However, the toxic mechanism of norgestrel (NG...

2025-09-10 | MTBLS12976 | MetaboLights
TranscriptomicsTranscriptome response to salinity stress in the Pacific oyster Crassostrea gigas
Low salinity is one of the main factors limiting the distribution and survival of marine species. As a euryhaline species, the Pacific oyster Crassostrea gigas can be tolerant to relative low salinity. Through Illumina sequencing, we generated two transcriptomes with samples taken from gills of oyst...
ORGANISM(S): Crassostrea gigas 
2012-12-15 | E-GEOD-38022 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression profilings between diploid and triploid Fujian Oyster
The systematic deep sequencing analysis provided a comprehensive understanding of the transcriptome complexity of 2n and 3n Fujian oyster. This information broadens our understanding of the mechanisms of C.angulata polyploidization and contributes to molecular and genetic research by enriching the o...
ORGANISM(S): Crassostrea angulata 
2014-03-06 | E-GEOD-55610 | biostudies-arrayexpress
Transcriptomicsoyster-OsHV-1 RNA-seq
Ostreid Herpesvirus type 1 (OsHV-1) has become a serious infective agent of the Pacific oyster livestock worldwide. In particular, the OsHV-1 muVar subtype has been associated to severe mortality episodes concerning Crassostrea gigas in France and other regions of the world such as Australia and New...
ORGANISM(S): Crassostrea gigas 
2014-12-31 | E-MTAB-2552 | biostudies-arrayexpress
GenomicsOyster microbiome
Oyster microbiome Metagenome
PRJNA839104 | ENA
TranscriptomicsDevelopment and validation of a 31,918-genes oyster cDNA Microarray: Tissue-specific expression profiles
Research using the oyster Crassostrea gigas as a model has experienced a rapid growth in recent years thanks to the development of high throughput molecular technologies. As many as 56,268 EST sequences have so far been sequenced, representing a genome-wide resource that can be used for microarray i...
ORGANISM(S): Crassostrea gigas 
2011-10-15 | E-GEOD-26265 | biostudies-arrayexpress
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