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TranscriptomicsRegions of XY homology in the pig X chromosome and the boundary of the pseudoautosomal region
Background Sex chromosomes are subject to evolutionary pressures distinct from the remainder of the genome, shaping their structure and sequence content. We are interested in the sex chromosomes of domestic pigs (Sus scrofa), how their structure and gene content compares and contrasts with other mam...
ORGANISM(S): Sus scrofa 
2012-08-30 | E-GEOD-40244 | biostudies-arrayexpress
UnknownCentral and local arterial stiffness in White Europeans compared to age-, sex-, and BMI-matched South Asians.
Not available
S-EPMC10449187 | biostudies-literature
TranscriptomicsMutant IDH inhibits HNF4a to disrupt hepatocyte differentiation and promote cholangiocarcinoma.
Gene expression of mouse hepatoblasts (HBs) expressing IDH1 WT, IDH1 R132C, IDH2 WT, R172K and empty vector controls (N=2 cultures for each condition) grown on collagen-coated plates and IDH1 R132C and empty vector controls on uncoated plates were evaluated using Affymetrix Mouse 430Av2 DNA microarr...
ORGANISM(S): Mus musculus 
2014-04-30 | E-GEOD-57002 | biostudies-arrayexpress
TranscriptomicsThe effect of periconceptional micronutrient supplementation on offspring DNA methylation
The effect of pre and periconceptional multiple micronutrient supplementation on methylation of CpG loci within CpG islands associated with 14,000 genes across the human genome has been investigated in the offspring of a cohort of Gambian women participating in a controlled double blinded trial. Met...
ORGANISM(S): Homo sapiens 
2012-03-15 | E-GEOD-34257 | biostudies-arrayexpress
TranscriptomicsSorted tumor RNA-seq of syngeneic murine mutant IDH1 ICC tumor model treated with IDH1 inhibitor against vehicle
IDH1 is the most commonly mutated metabolic gene across human cancers, with the highest mutational frequency observed in AML, glioma, chondrosarcoma, and intrahepatic cholangiocarcinoma. Mutations of the hot spot R132 codon alter the activity of the IDH1 enzyme, resulting in the NADPH-dependent conv...
ORGANISM(S): Mus musculus 
2021-11-23 | E-MTAB-11112 | biostudies-arrayexpress
UnknownDeath following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.
Not available
S-EPMC10364875 | biostudies-literature
TranscriptomicsLKB1 modulates lung cancer differentiation and metastasis
Inherited mutation in LKB1 results in the Peutz-Jeghers syndrome (PJS), characterized by intestinal hamartomas and a modestly increased frequency of gastrointestinal and breast cancer1. Somatic inactivation of LKB1 occurs in human lung adenocarcinoma2-4, but its tumor suppressor role in this tissue ...
ORGANISM(S): Homo sapiens 
2007-08-28 | E-GEOD-6135 | biostudies-arrayexpress
TranscriptomicsD-2-Hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) have been discovered in several cancer types and cause the neurometabolic syndrome D2-Hydroxyglutaric aciduria (D2HGA). The mutant enzymes exhibit neomorphic activity resulting in production of D2- hydroxyglutaric acid (D-2HG). To study the pat...
ORGANISM(S): Mus musculus 
2014-03-01 | E-GEOD-54838 | biostudies-arrayexpress
UnknownPredictive Approaches for Acute Dialysis Requirement and Death in COVID-19.
Not available
S-EPMC8455052 | biostudies-literature
UnknownOutcomes of Patients on Maintenance Dialysis Hospitalized with COVID-19.
Not available
S-EPMC8011022 | biostudies-literature
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