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Mycoplasmopsis bovis strain:P150 Genome sequencing
mRNASeq of kidney, liver, and cerebellum of P195A/p150- and P195A/p150+ mice
The goal of this experiement was to determine what transcriptional differences there are between P195A/p150- (sick) and P195A/p150+ (healthy) mice. Kidney, Liver, and Cerebellum were the most clearly affected on histology and qPCR for IFN. We found an IFN signature and ISR signature were both upregu...
ORGANISM(S): Mus musculus 
2021-08-26 | GSE162583 | GEO
Targeting the ADAR1 p150 isoform to overcome immunotherapy resistance
Retrotransposons are widely spread in the mammalian genome and are usually silenced during development to avoid transposition-inducing mutations. But how they are repressed in embryos shortly before implantation remain to be identified, since the genome at this stage is globally hypomethylated. Here...
ORGANISM(S): Mus musculus 
RNA-seq of control siRNA, p150 siRNA and p60 siRNA transfected mES cells
ADAR1-editing in HeLa, p150-KO and ADAR1-KO transcriptomes
Cancer immunotherapy efficacy is often limited by primary and acquired resistance. The RNA-editing enzyme ADAR1 has emerged as a key regulator of tumor immune evasion, yet therapeutic targeting is challenged by the essential physiological roles of its constitutively expressed p110 isoform. Here, we ...
ORGANISM(S): Mus musculus 
2026-04-12 | GSE314521 | GEO
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