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TranscriptomicsTranscription profiling of human Mo7e cells transduced with control- or p210(BCR-ABL)-GFP viruses
The profiles of transcripts of Mo7e cells transduced with control- or p210(BCR-ABL)-GFP viruses were compared using microarrays to investigate
ORGANISM(S): Homo sapiens 
2007-10-31 | E-TABM-173 | biostudies-arrayexpress
ProteomicsFunctional proteomics defines differential signaling networks of the oncogenic kinases Bcr-Abl p210 and p185
The two major isoforms of the oncogenic Bcr-Abl tyrosine kinase, p210 and p185, are expressed upon the Philadelphia chromosome translocation. p210 is the hallmark of chronic myelogenous leukemia, whereas p185 occurs in the majority of B-cell acute lymphoblastic leukemia. Differences in protein-prote...
ORGANISM(S): Mus musculus (Mouse) 
2017-01-31 | PXD005149 | Pride
Leukemia Bcr-abl tyrosine kinase Interactome Silac Phosphoproteome 
TranscriptomicsRetroviral transduction of CD34+ cells with P190 and P210 BCR/ABL1 fusion genes
Expression of P190 and P210 BCR/ABL1 in normal human CD34(+) cells induces similar gene expression profiles and results in a STAT5-dependent expansion of the erythroid lineage The P190 and P210 BCR/ABL1 fusion genes are mainly associated with different types of hematologic malignancies, but it is pr...
ORGANISM(S): Homo sapiens 
2009-05-12 | GSE16042 | GEO
GenomicsMutation Detection in p210 kinase domain
Mutation Detection in p210 kinase domain
PRJNA1303185 | ENA
UnknownThe RhoGEF domain of p210 Bcr-Abl activates RhoA and is required for transformation.
Not available
S-EPMC2676674 | biostudies-literature
UnknownRequirement of c-Myb for p210(BCR/ABL)-dependent transformation of hematopoietic progenitors and leukemogenesis.
Not available
S-EPMC2343605 | biostudies-literature
UnknownDifferential signaling networks of Bcr-Abl p210 and p190 kinases in leukemia cells defined by functional proteomics.
Not available
S-EPMC5508078 | biostudies-literature
UnknownLoss of the xeroderma pigmentosum group B protein binding site impairs p210 BCR/ABL1 leukemogenic activity.
Not available
S-EPMC3763389 | biostudies-literature
UnknownDistinct outcomes, ABL1 mutation profile, and transcriptome features between p190 and p210 transcripts in adult Philadelphia-positive acute lymphoblastic leukemia in the TKI era.
Not available
S-EPMC8915539 | biostudies-literature
UnknownUbiquitin-mediated interaction of p210 BCR/ABL with β-catenin supports disease progression in a murine model for chronic myelogenous leukemia.
Not available
S-EPMC3778552 | biostudies-literature
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