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TranscriptomicsThe ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue
Inflammasome activation in adipose tissue has been implicated in obesity-associated insulin resistance and type 2 diabetes. However, when and how inflammasome is activated in adipose tissue remains speculative. Here we test the hypothesis that extracellular ATP, a potent stimulus of inflammasome in ...
ORGANISM(S): Mus musculus 
2012-02-24 | E-GEOD-36033 | biostudies-arrayexpress
GenomicsGene expression profile of Wild Type (WT) and P2x7 knockout (P2X7-KO) leukemia leukemia-initiating cells Transcriptomes
Gene expression profile of Wild Type (WT) and P2x7 knockout (P2X7-KO) leukemia leukemia-initiating cells Transcriptomes
PRJNA681910 | ENA
TranscriptomicsGene expression profile of Wild Type (WT) and P2x7 knockout (P2X7-KO) leukemia leukemia-initiating cells Transcriptomes
To determine the underlying molecular mechanisms that control the homing and self-renewal activities of P2x7-null Mac-1+c-Kit+ LICs, WT and P2x7-null LICs were WT and P2x7-KO were sorted by flow cytometry, followed by the extraction of total RNA and subjected to the RNA-sequencing.
ORGANISM(S): Mus musculus 
2023-11-30 | GSE162468 | GEO
TranscriptomicsGenetic deletion of P2X7 receptors causes genome-wide alteration of gene expression and results in antidepressant phenotype in mice amygdale
The purpose of the study was to explore the role of P2X7 receptors (P2X7R) in mood related behavior we have employed whole genome microarray expression profiling as a discovery platform.To identify genes affected by the genetic deletion of P2X7 receptors in the mouse amygdala we performed gene expre...
ORGANISM(S): Mus musculus 
2011-03-31 | E-GEOD-21218 | biostudies-arrayexpress
GenomicsP2X7 receptor-dependent microRNA expression profile in the brain following status epilepticus in mice
P2X7 receptor-dependent microRNA expression profile in the brain following status epilepticus in mice
PRJNA641719 | ENA
TranscriptomicsP2X7 receptor-dependent microRNA expression profile in the brain following status epilepticus in mice
We explored the microRNA expression profile in mice lacking the P2X7 receptor before and after seizures. Genome-wide microRNA profiling was performed using hippocampi from wild-type and P2X7 knock-out mice following status epilepticus induced by intraamygdala kainic acid. This revealed that genetic ...
ORGANISM(S): Rattus norvegicus Mus musculus 
2020-06-25 | GSE153204 | GEO
ProteomicsP2X7 signaling drives Th1 cell differentiation through metabolic reprogramming for aerobic glycolysis
This study provides evidence on the molecular mechanisms by which P2RX7 signaling promotes Th1 cell differentiation. P2RX7 induces T-bet expression and aerobic glycolysis in splenic CD4+ T cells that respond to malaria, at a time prior to Th1/Tfh polarization. Cell-intrinsic P2RX7 signaling sustains...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-08 | PXD037754 | Pride
Aerobic glycolysis Malaria P2x7 signaling Th1 cell differentiation 
GenomicsNext Generation Sequencing Facilitates Quantitative Analysis of DLBCL Cell Line SU-DHL-4 Cells with P2X7 Receptor Signaling Activation or Inhibition
Next Generation Sequencing Facilitates Quantitative Analysis of DLBCL Cell Line SU-DHL-4 Cells with P2X7 Receptor Signaling Activation or Inhibition
PRJNA934290 | ENA
TranscriptomicsGene expression changes in wide-type P2X7 overexpressed MLL-AF9 induced mouse acute myeloid leukemia (AML)
P2X7 was significantly up-regulated in leukemia patients, especially in AML (MLL-AF9) and often related to poor prognosis.We compared the transcriptomic changes in MLL-AF9 induced mouse AML and overexpressed wP2X7 in MLL-AF9 induced AML. Engaged to explore the mechanism of P2X7 in leukemia progressi...
ORGANISM(S): Mus musculus 
2021-12-29 | GSE92969 | GEO
TranscriptomicsThe ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue
Inflammasome activation in adipose tissue has been implicated in obesity-associated insulin resistance and type 2 diabetes. However, when and how inflammasome is activated in adipose tissue remains speculative. Here we test the hypothesis that extracellular ATP, a potent stimulus of inflammasome in ...
ORGANISM(S): Mus musculus 
2012-02-24 | GSE36033 | GEO
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