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TranscriptomicsThe ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue
Inflammasome activation in adipose tissue has been implicated in obesity-associated insulin resistance and type 2 diabetes. However, when and how inflammasome is activated in adipose tissue remains speculative. Here we test the hypothesis that extracellular ATP, a potent stimulus of inflammasome in ...
ORGANISM(S): Mus musculus 
2012-02-24 | E-GEOD-36033 | biostudies-arrayexpress
ProteomicsP2X7 signaling drives Th1 cell differentiation through metabolic reprogramming for aerobic glycolysis
This study provides evidence on the molecular mechanisms by which P2RX7 signaling promotes Th1 cell differentiation. P2RX7 induces T-bet expression and aerobic glycolysis in splenic CD4+ T cells that respond to malaria, at a time prior to Th1/Tfh polarization. Cell-intrinsic P2RX7 signaling sustains...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-08 | PXD037754 | Pride
Aerobic glycolysis Malaria P2x7 signaling Th1 cell differentiation 
GenomicsNext Generation Sequencing Facilitates Quantitative Analysis of DLBCL Cell Line SU-DHL-4 Cells with P2X7 Receptor Signaling Activation or Inhibition
Next Generation Sequencing Facilitates Quantitative Analysis of DLBCL Cell Line SU-DHL-4 Cells with P2X7 Receptor Signaling Activation or Inhibition
PRJNA934290 | ENA
GenomicsNext Generation Sequencing Facilitates Quantitative Analysis of HCC Cell Line HepG2 Cells with Inhibited P2X7 Receptor Signaling by Antagonist A740003 or A438079
Next Generation Sequencing Facilitates Quantitative Analysis of HCC Cell Line HepG2 Cells with Inhibited P2X7 Receptor Signaling by Antagonist A740003 or A438079
PRJNA1117474 | ENA
GenomicsTubular epithelial cells promote macrophage pyroptosis through PANX1-extracellular ATP-P2X7 signaling in aldosterone-dependent renal injury
Tubular epithelial cells promote macrophage pyroptosis through PANX1-extracellular ATP-P2X7 signaling in aldosterone-dependent renal injury
PRJNA1453951 | ENA
TranscriptomicsGenetic deletion of P2X7 receptors causes genome-wide alteration of gene expression and results in antidepressant phenotype in mice amygdale
The purpose of the study was to explore the role of P2X7 receptors (P2X7R) in mood related behavior we have employed whole genome microarray expression profiling as a discovery platform.To identify genes affected by the genetic deletion of P2X7 receptors in the mouse amygdala we performed gene expre...
ORGANISM(S): Mus musculus 
2011-03-31 | E-GEOD-21218 | biostudies-arrayexpress
TranscriptomicsThe ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue
Inflammasome activation in adipose tissue has been implicated in obesity-associated insulin resistance and type 2 diabetes. However, when and how inflammasome is activated in adipose tissue remains speculative. Here we test the hypothesis that extracellular ATP, a potent stimulus of inflammasome in ...
ORGANISM(S): Mus musculus 
2012-02-24 | GSE36033 | GEO
UnknownImpaired LPS Signaling in Macrophages Overexpressing the P2X7 C-Terminal Domain or Anti-P2X7 C-Terminal Domain Intrabody.
Not available
S-EPMC11818346 | biostudies-literature
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of DLBCL Cell Line SU-DHL-4 Cells with P2X7 Receptor Signaling Activation or Inhibition
The goals of this study aim to reveal the role of P2X7 receptor signaling in DLBCL
ORGANISM(S): Homo sapiens 
2023-07-12 | GSE225174 | GEO
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of HCC Cell Line HepG2 Cells with Inhibited P2X7 Receptor Signaling by Antagonist A740003 or A438079
The goals of this study aim to reveal the role of P2X7 receptor signaling in HCC
ORGANISM(S): Homo sapiens 
2024-11-27 | GSE268508 | GEO
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