Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse models with liver-specific deletion or global hypomorphic expression of the NADPH-cytochrome P450 reductase gene to study molecular mechanisms for the regulation of microsomal cytochrome P450 and the fatty liver phenotype.
NADPH-cytochrome P450 reductase (CPR) is important for the functions of many enzymes, such as microsomal cytochrome P450 (P450) monooxygenases and heme oxygenases. Two mouse models with deficient CPR expression in adults were recently generated in this laboratory: liver-Cpr-null (with liver-specific...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2362 | biostudies-arrayexpress
ProteomicsProteomic Consequences of the Deletion of Cytochrome P450 (CYP450) Reductase in Mice
Microsomal cytochrome P450 (CYP450) reductase enzymes play a major role in drug and xenobiotic metabolism. Mice which are deficient in hepatic CYP450 reductase serve as excellent models in understanding CYP450 drug metabolism and alterations in the underlying biology. A reversed-phase nano-bore UPLC...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-26 | PXD024420 | Pride
Proteomics  cytochrome p450  lipid metabolism  bile acids  glutathione Tca cycle. 
GenomicsEndothelial deletion of the cytochrome P450 reductase leads to cardiac remodelling
Endothelial deletion of the cytochrome P450 reductase leads to cardiac remodelling
PRJNA887058 | ENA
Genomics
Cytochrome P450 CYP4G subfamily and P450 reductase gene function in Tuta absoluta
PRJNA1380754 | ENA
TranscriptomicsAltered gene expression in the small intestine of IE-Cpr-null mice
The NADPH-cytochrome P450 reductase (CPR) is essential for the functioning of microsomal cytochrome P450 (P450) monoxygenases. The biological functions of the CPR-dependent enzymes in the intestine are not known, despite the vast knowledge available on the biochemical properties of the various oxyge...
ORGANISM(S): Mus musculus 
2012-04-10 | E-GEOD-35293 | biostudies-arrayexpress
UnknownAllosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain.
Not available
S-EPMC10481364 | biostudies-literature
UnknownThe interaction of microsomal cytochrome P450 2B4 with its redox partners, cytochrome P450 reductase and cytochrome b(5).
Not available
S-EPMC3073529 | biostudies-literature
UnknownProbing membrane enhanced protein-protein interactions in a minimal redox complex of cytochrome-P450 and P450-reductase.
Not available
S-EPMC7467500 | biostudies-literature
TranscriptomicsEndothelial deletion of the cytochrome P450 reductase leads to cardiac remodelling
The cytochrome P450 reductase (POR) transfers electrons to all microsomal cytochrome P450 enzymes (CYP450) thereby driving their activity. In the vascular system, the POR/CYP450 system has been linked to the production of epoxyeicosatrienoic acids (EETs) but also to the generation of reactive oxygen...
ORGANISM(S): Mus musculus 
2022-12-21 | GSE214776 | GEO
UnknownConformational Landscape of Cytochrome P450 Reductase Interactions.
Not available
S-EPMC7864194 | biostudies-literature
Sort   by:  
 Page size