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ProteomicsProteomics of human Vγ9Vδ2-T cells treated with BSA, PA, or OA by LC-MS/MS
To better understand the mechanisms underlying the different antitumor activity of Vγ9Vδ2-T cells induced by PA or OA, we performed the proteomic analysis of Vγ9Vδ2-T cells cultured under different conditions.
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD064016 | Pride
Proteomics Human vγ9vδ2-t cells Pa or oa Lc-ms/ms 
TranscriptomicsTranscriptomic effects of Ocean Acidification and their modulation by energy availability in the life-cycle stages of the coccolithophore Emiliania huxleyi
To investigate the effects of ocean acidification (OA) and their energy-dependent modulation in the life-cycle stages of E.huxleyi, diploid and haploid cells were acclimated to present and future CO2 partial pressures (pCO2; 38.5 Pa vs. 101.3 Pa CO2) under low and high light (50 vs. 300 M-5mol photo...
ORGANISM(S): Emiliania huxleyi 
2012-11-01 | E-MEXP-3624 | biostudies-arrayexpress
TranscriptomicsCTL-OA-OP human IT PF Bone - CompuGen H19K microarray study
Aims of study: (1) To identify systemic differences in osteoarthritic (OA) bone that contribute to OA pathogenesis. (2) Identify novel osteoporotic (OP) bone-related disease genes. Study involved comparison of trabecular bone extracted from the intertrochanteric (IT) region of the proximal femur (PF...
ORGANISM(S): Homo sapiens 
2008-01-14 | E-GEOD-8406 | biostudies-arrayexpress
UnknownPA and OA induce abnormal glucose metabolism by inhibiting KLF15 in adipocytes.
Not available
S-EPMC8607635 | biostudies-literature
TranscriptomicsEicosapentaenoic acid improves metabolic switching in human myotubes
Metabolically healthy skeletal muscle is characterized by the ability to switch easily between glucose and fat oxidation, whereas loss of this ability seems to be related to insulin resistance. The aim of this study was to investigate whether different fatty acids (FAs) and the LXR ligand T0901317 a...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-18589 | biostudies-arrayexpress
Proteomicsthe Effect of Fatty Acids in Hepatic Insulin resistance-part2
Monounsaturated fatty acid (MUFA) oleic acid (OA) has been reported to reverse saturated fatty acid palmitic acid (PA)-induced hepatic insulin resistance (IR). However, the detailed molecular mechanism remains elusive. In addition, previous research also showed that -3 polyunsaturated fatty acid (PU...
ORGANISM(S): Homo sapiens (Human) 
2019-07-11 | PXD012066 | Pride
Human  free fatty acids  insulin resistance  quantitative proteomics  calcium  atp. 
ProteomicsEpithelial-mesenchymal transition shapes the lipotoxic response of colon cancer cells to palmitic acid
Saturated fatty acids such as palmitic acid (PA) can induce lipotoxic stress, whereas monounsaturated fatty acids like oleic acid (OA) often promote adaptive responses through lipid droplets (LDs) formation. Here, we reveal that epithelial-mesenchymal transition (EMT) profoundly influences the lipot...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD071641 | Pride
Emt markers  lipotoxicity  palmitic acid  lipid droplets  metabolic reprogramming. 
TranscriptomicsGene expression data from differentiated 3T3-L1 preadipocytes treated with Palmitic Acid, Stearic Acid, Palmitoleic Acid, or Oleic Acid
Saturated fatty acids (SFA) are widely thought to induce inflammation in adipose tissue (AT), while monounsaturated fatty acids (MUFA) are purported to have the opposite effect; however, it is unclear if individual SFA and MUFA behave similarly. Our goal was to examine adipocyte transcriptional netw...
ORGANISM(S): Mus musculus 
2012-11-13 | E-GEOD-42220 | biostudies-arrayexpress
TranscriptomicsExposure of bovine oocytes and embryos to elevated non-esterified fatty acid concentrations: integration of epigenetic and transcriptomic signatures in resultant blastocysts [DNA methylation]
Metabolic stress associated with negative energy balance in high producing dairy cattle and obesity in women is a risk factor for decreased fertility. Non-esterified fatty acids (NEFA) are involved in this pathogenesis as they jeopardize oocyte and embryo development. Growing evidence indicates that...
ORGANISM(S): Bos taurus 
2016-06-28 | E-GEOD-83766 | biostudies-arrayexpress
UnknownOsteoarthritis physical activity care pathway (OA-PCP): results of a feasibility trial.
Not available
S-EPMC7229580 | biostudies-literature
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